Only 20 years after the discovery of the hepatitis C virus, a cure is now likely for most people with chronic infection. The latest review in our Drug Therapy series considers current therapy and the present landscape of drug development for hepatitis C. The hepatitis C virus (HCV) carries a substantial disease burden, not only… Read More…
In two new randomized, controlled studies involving patients undergoing long-term hemodialysis, peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent, was compared with epoetin for the treatment of anemia. The two agents were similarly effective. Read both the EMERALD study and the PEARL study here. Partial correction of anemia with erythropoiesis-stimulating agents (ESAs) is a cornerstone of therapy… Read More…
In the latest Case Record of the Massachusetts General Hospital, a 62-year-old man was admitted to this hospital because of paresthesias, weight loss, jaundice, and anemia. Diagnostic test results were received. Paresthesias involve a sensation of tingling, numbness, crawling, or deadness, and they are felt mainly in distal parts of the extremities. Although they very rarely involve… Read More…
In the latest Case Record of the Massachusetts General Hospital, a 62-year-old woman with autoimmune overlap syndrome and polymyositis presented with anemia, thrombocytopenia, and acute renal failure. Four days before admission, she was found on the floor of her home, confused and minimally conversant. Approximately 70% of patients with diffuse cutaneous systemic sclerosis have kidney involvement,… Read More…
In the latest Case Record of the Massachusetts General Hospital, a 62-year-old woman presented with dyspnea, anemia, and paraspinal masses. Examination revealed splenomegaly. Laboratory studies revealed microcytic anemia. A diagnostic test result was received. A common feature of all thalassemias is that clinical symptoms arise less from the deficit in hemoglobin production than from the accumulation… Read More…
