Posts Tagged ‘chemotherapy’

Prophylaxis against Venous Thromboembolism in Ambulatory Cancer Patients

Posted by Sara Fazio • June 27th, 2014

Patients with cancer are at increased risk for thrombosis, and those with thrombi have poorer overall survival rates than those without. In a new review article, Dr. Jean Connors from Brigham and Women’s Hospital and Dana Farber Cancer Institute summarizes available data and provides guidance for determining which patients might benefit from thromboprophylaxis. The incidence… Read More…

Circulating Tumor DNA

Posted by Jamie Colbert • March 27th, 2013

Fifty years ago, oncologists relied upon the clinical exam to follow breast cancer patients with metastatic disease. Patients were treated with chemotherapy, and then the physicians waited for symptoms to return before deciding on the next treatment course. Some patients could go months or even years without symptoms, but during this time they played a… Read More…

Brain Mass

Posted by Sara Fazio • May 31st, 2012

In this week’s Case Record of the Massachusetts General Hospital, a 54-year-old man had transient then persistent partial loss of vision. Images of the brain showed two adjacent masses in the left occipital and posterior parietal regions. A diagnostic procedure was performed. Glioblastoma is a highly malignant tumor, with a median survival of 9 to 14… Read More…

Breast Cancer

Posted by Graham McMahon • October 5th, 2011

In a study from Slamon et al., trastuzumab added to a nonanthracycline regimen to treat HER2-positive breast cancer resulted in rates of disease-free and overall survival that were similar to those for an anthracycline-containing regimen, with lower rates of cardiac toxicity and secondary leukemia. The HER2 gene encodes a tyrosine kinase receptor that mediates critical… Read More…

Metastatic Pancreatic Cancer

Posted by Graham McMahon • May 13th, 2011

In a new study from Conroy et al., a four-drug combination chemotherapy regimen was associated with objective responses in more than 30% of patients and increased survival by more than 4 months, as compared with standard gemcitabine. Pancreatic adenocarcinoma was the fourth leading cause of death from cancer in the United States in 2010, and… Read More…

Nanomedicine

Posted by Graham McMahon • December 17th, 2010

The latest article in our Current Concepts review series, “Nanomedicine,” comes from Drs. Betty Kim, James Rutka, and Warren Chan of the University of Toronto. The field of nanomedicine aims to apply nanotechnology to the diagnosis and treatment of diseases at the molecular level. Clinical Pearls • What do nanomaterials consist of? Nanomaterials generally consist of… Read More…