Posts Tagged ‘colorectal cancer’

A Boy with Abdominal Cramping

Posted by • February 26th, 2016

Colorectal carcinoma is extremely uncommon in children. Hereditary cancer syndromes may confer a predisposition to colorectal carcinoma in children. A 10-year-old boy was seen in the gastroenterology clinic because of abdominal cramping and fevers. Abdominal imaging studies revealed circumferential thickening of a segment of the colonic wall and mesenteric lymphadenopathy. A diagnostic procedure was performed. A new Case… Read More…

Refractory Metastatic Colon Cancer

Posted by • May 15th, 2015

TAS-102, a combination of trifluridine and tipiracil in which tipiracil interferes with the deactivation of trifluridine, improved overall and progression-free survival in patients whose disease had progressed after treatment with fluorouracil-containing drug combinations. A new Original Article assesses the efficacy and safety of TAS-102 in a global population of such patients. Early clinical trials conducted primarily… Read More…

Inflammatory Bowel Disease

Posted by • April 9th, 2015

A new review article covers the wide range of cancers associated with inflammatory bowel disease and the drugs used to manage them. Surveillance recommendations are presented. Cancers complicating inflammatory bowel disease can be attributed to chronic intestinal inflammation or to the carcinogenic effects of the immunosuppressive drugs used to treat inflammatory bowel disease. Clinical Pearls – What… Read More…

Adenoma Detection Rate and Colorectal Cancer

Posted by • April 2nd, 2014

Your patient recently celebrated her 50th birthday. After a few weeks of partying, she’s ready to turn to the less glamorous work that comes with having lived half a century.  First up is the colonoscopy. She’s impressively well informed and so it’s not a surprise when she comes to your primary care office with a question…. Read More…

Colorectal Cancer after Lower Endoscopy

Posted by • September 18th, 2013

There’s no question that colon cancer screening saves lives. But the preferred screening method – colonoscopy or the less invasive and less costly sigmoidoscopy – remains an area of uncertainty. Colonoscopy should, intuitively, perform better.  After all, the scope travels beyond the reach of the sigmoidoscopy, allowing a doctor to inspect the proximal intestine for any… Read More…

Anti–PD-L1 Antibody in Patients with Advanced Cancer

Posted by • June 27th, 2012

In the late 19th century, surgical oncologist William Coley reported the story of a patient with a sarcoma whose disease had gone into complete remission following an untreated strep infection at the site of the tumor.  At the time, Coley – who had recently witnessed the death of a young patient of his own from… Read More…

Flexible Sigmoidoscopy and Colorectal Cancer

Posted by • June 22nd, 2012

After nearly 12 years of follow-up, the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial has shown that screening with flexible sigmoidoscopy reduces colorectal-cancer incidence by 21% and mortality by 26%. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Colorectal-cancer mortality and incidence are reduced with screening by means of… Read More…

A More Flexible Outlook on Colorectal Cancer Screening

Posted by • June 20th, 2012

At age 65, Mrs. P., a patient recently seen in clinic, had never had a colonoscopy.  She understood the rationale for undergoing colorectal cancer screening and the risks of not doing so – but year after year, when colonoscopy was offered, she chose to defer action. For patients like Mrs. P. who shy away from screening… Read More…

Ulcerative Colitis

Posted by • November 4th, 2011

Ulcerative colitis is the most common form of inflammatory bowel disease. Its course is often mild, with few complications, and it can be cured by colectomy. Our current understanding of its pathophysiology, diagnosis, and treatment is reviewed in a new Medical Progress article. Ulcerative colitis is the most common form of inflammatory bowel disease worldwide. In… Read More…