Posts Tagged ‘placebo’

Dupilumab versus Placebo in Atopic Dermatitis

Posted by • December 15th, 2016

For patients with moderate-to-severe atopic dermatitis, topical therapies have limited efficacy, and systemic treatments are associated with substantial toxic effects. Thus, there is an unmet need for effective and safe long-term medications for these patients. Simpson et al. reported the results of two phase 3 trials of dupilumab monotherapy (SOLO 1 and SOLO 2) in… Read More…

Semaglutide in Patients with Type 2 Diabetes

Posted by • November 10th, 2016

Regulatory guidance specifies the need to establish cardiovascular safety of new diabetes therapies in patients with type 2 diabetes in order to rule out excess cardiovascular risk. The preapproval Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) conducted by Marso et al. was designed to assess… Read More…

Liraglutide in Type 2 Diabetes

Posted by • July 28th, 2016

To assess the long-term effects of liraglutide on cardiovascular outcomes and other clinically important events, the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial was initiated in 2010. Patients with type 2 diabetes who had a glycated hemoglobin level of 7.0% or more were eligible if they either had not… Read More…

Perioperative Bridging Anticoagulation

Posted by • August 28th, 2015

In this Original Article, a trial assigned patients with atrial fibrillation who required warfarin interruption for an elective procedure to either bridging anticoagulation or placebo. Forgoing bridging was noninferior to bridging for arterial thromboembolism and superior for major bleeding. A video summary is also available with the article on NEJM.org. For patients with atrial fibrillation who… Read More…

Pleural Infection

Posted by • August 12th, 2011

Slowly clearing infections in the pleural space are a source of substantial morbidity. A new study published this week in NEJM showed that instillation of recombinant DNase and tissue plasminogen activator (t-PA) is more effective than placebo in clearing radiographic pleural effusions. The mortality rate from pleural infection is between 10% and 20%. The investigators in… Read More…

Breathing Easy

Posted by • July 13th, 2011

If a treatment for asthma makes an asthma patient feel better, did it work?  It’s hard to say, according to an article by Wechsler et al published this week in NEJM.  The authors report the results of a randomized double-blind crossover pilot study comparing the effectiveness of four interventions: an active albuterol inhaler, a placebo… Read More…