Posts Tagged ‘pulmonary embolism’

60 Year-Old Woman with Syncope

Posted by Sara Fazio • September 19th, 2014

In the latest Case Record of the Massachusetts General Hospital, a 60-year-old woman was seen in the emergency department after a syncopal episode. Oxygen saturation was 71% while she was breathing ambient air. A focused cardiac ultrasound revealed right-sided heart strain and McConnell’s sign. Additional diagnostic procedures were performed. A FOCUS examination, also referred to… Read More…

Two novel agents for extended treatment of venous thromboembolism

Posted by Jamie Colbert • February 20th, 2013

Venous thromboembolic disease (VTE) and pulmonary embolism have been major causes of human morbidity and mortality for thousands of years, yet our understanding of the pathobiology of this disease was rudimentary until the 1840s when German pathologist Rudolf Virchow discovered that blood clots in large veins of the lower legs could travel through the right… Read More…

Life after PE: Can Rivaroxaban Be the New Warfarin?

Posted by Rena Xu • April 4th, 2012

Most patients who are found to have a pulmonary embolism are started on a medication to prevent future clots.  For years, the drug of choice has been warfarin, a vitamin K antagonist that decreases the level of clotting factors.  This medication works well but is notoriously complicated to use, requiring frequent monitoring with blood draws… Read More…

Pulmonary Thrombotic Microangiopathy

Posted by Graham McMahon • January 6th, 2012

In our latest Clinical Problem-Solving article, a 50-year-old woman presented with fatigue and shortness of breath. Dyspnea after moderate exertion had developed gradually, along with profound malaise and a nonproductive cough. In the 48 hours before admission, her shortness of breath had worsened.     The clinicopathological syndrome of subacute cor pulmonale caused by tumor microemboli to… Read More…

Low-Molecular-Weight Heparin in Medical Patients

Posted by Sara Fazio • December 30th, 2011

Pharmacologic thromboprophylaxis has been proven to reduce the incidence of venous thromboembolism in both  surgical patients and acutely ill medical patients. In surgical patients, thromboprophylaxis has been shown to reduce  the incidence of fatal pulmonary embolism and the rate of death from any cause; in medical patients, studies have  shown that thromboprophylaxis is associated with… Read More…

Acute Pulmonary Embolism

Posted by Graham McMahon • July 16th, 2010

Pulmonary embolism should be suspected in all patients who present with new or worsening dyspnea, chest pain, or sustained hypotension without an obvious alternative cause. The diagnostic workup should be tailored to the severity of the clinical presentation on the basis of whether the patient is hemodynamically stable or unstable.  A review by Agnelli et… Read More…