Posts Tagged ‘trial’

The 70-Gene Signature as an Aid to Treatment Decisions in Early Breast Cancer

Posted by • August 24th, 2016

“Your cancer has been successfully removed with surgery, but there may be a role for chemotherapy to protect you in the future.” This message is expressed by oncologists in consulting rooms all over the world. In women with early-stage breast cancer, adjuvant chemotherapy may be offered as an insurance policy against cancer recurrence. Risk of… Read More…

Life after PE: Can Rivaroxaban Be the New Warfarin?

Posted by • April 4th, 2012

Most patients who are found to have a pulmonary embolism are started on a medication to prevent future clots.  For years, the drug of choice has been warfarin, a vitamin K antagonist that decreases the level of clotting factors.  This medication works well but is notoriously complicated to use, requiring frequent monitoring with blood draws… Read More…

Donepezil and Memantine for Alzheimer’s Disease

Posted by • March 7th, 2012

All of us who have completed an internship are well-familiar with the poly-pharmacy-discharge challenge. The patient comes in on eight medications. Now it’s time to go home, and you’ve gone and added another four. Surely the patient doesn’t need all of these, but as you review her list, it’s not clear that any can be… Read More…

Ruxolitinib for Myelofibrosis

Posted by • March 2nd, 2012

A new trial from Verstovsek and others showed clinically significant responses in spleen size and quality of life among patients with myelofibrosis receiving the ruxolitinib, a JAK1 and JAK2 inhibitor. The agent has some myelotoxicity, but this study showed a survival advantage with ruxolitinib. Myelofibrosis, a myeloproliferative neoplasm, is manifested by abnormal blood counts (anemia, thrombocytosis or… Read More…

Niacin in Patients with Low HDL Receiving Statins

Posted by • December 14th, 2011

A 65 year-old man with known coronary disease comes to your office seeking advice. He had his first MI at age 56, had PCI at the time, and has been medically managed since. His LDL is below 70 on 40 mg of simvastatin, but his HDL has always been stubbornly low, hovering in the low… Read More…