Posts Tagged ‘tuberculosis’

Injuries

Posted by Sara Fazio • May 3rd, 2013

Injuries, whether intentional or unintentional, account for a substantial burden on the health care system. The latest article in our new Global Health series describes the magnitude of the problem worldwide, enumerates ongoing efforts to prevent injuries, and summarizes systems that need to be in place to care for the injured. In 2010, there were… Read More…

Tuberculosis

Posted by Sara Fazio • February 22nd, 2013

In 2011, there were 8.7 million new cases of active tuberculosis worldwide. Recent advances in diagnostics, drugs, and vaccines and enhanced implementation of interventions are helping to improve the prospects for global tuberculosis control. The latest review in our Current Concepts series covers the diagnosis and treatment of latent, active, and drug-resistant tuberculosis and also… Read More…

Linezolid in XDR – Useful to an Extent

Posted by Sushrut Jangi • October 18th, 2012

A few hours north of Durban, South Africa, the little town of Tugela Ferry sits in the shadow of the rugged mountains that run alongside the Indian Ocean.  There are few roads here, gaps in the electrical grid, and a paucity of running water.   The main hospital in town – the three-hundred-and-fifty bed Church of… Read More…

Fever and Back Pain

Posted by Sara Fazio • August 24th, 2012

In the latest Case Record of the Massachusetts General Hospital, a 70-year-old woman was admitted because of intermittent fevers and new-onset back and leg pain. Imaging of the lumbar spine revealed abnormalities in the vertebral bodies adjacent to the L5–S1 disk space. A diagnostic result was received. Brucellosis is widespread in the Middle East. Serologic… Read More…

Aspiring to Make MDR-TB Nevermore: Delamanid for Multi-drug Resistant Pulmonary Tuberculosis

Posted by John Staples • June 6th, 2012

Edgar Allan Poe (b. 1809; d. 1849), master of the macabre, had good reason to be terrified by “the redness and the horror of blood”[1] – particularly when it arrived in a fit of coughing. Consumption (almost certainly due to pulmonary tuberculosis) orphaned Poe before the age of three, and later caused the death of… Read More…

Tuberculosis

Posted by Sara Fazio • December 9th, 2011

Treatment of latent TB is an important public-health strategy, but 9 months of daily isoniazid (270 doses) poses challenges for compliance. In a new study, 3 months of weekly isoniazid plus rifapentine (12 doses) was found to be noninferior to 9 months of isoniazid alone. Tuberculosis results in nearly 2 million deaths annually worldwide. Treatment… Read More…

Antiretroviral Therapy and Tuberculosis

Posted by Graham McMahon • October 21st, 2011

When to initiate antiretroviral therapy in patients with newly diagnosed HIV infection and TB has been debated. In a new study from Cambodia, giving antiretrovirals 2 weeks after the start of TB therapy was superior to therapy begun at 8 weeks, with a decrease in mortality. Tuberculosis is a major cause of death in persons… Read More…

Prevention of HIV Transmission

Posted by Graham McMahon • August 12th, 2011

In a large, international study of HIV-1–serodiscordant couples, the receipt of antiretroviral therapy by the infected partner decreased transmission to the uninfected partner as well as rates of clinical events in the HIV-1–infected partner. Because the sexual transmission of HIV-1 from infected persons to their partners is strongly correlated with concentrations of HIV-1 in blood and in… Read More…

Treatment as Prevention

Posted by John Staples • August 10th, 2011

Just for a moment, imagine that you’ve just finished treating me for active pulmonary tuberculosis. I’m cured and therefore happy. What’s more, my future roommates are happy: I’ll no longer aerosolize inocula of acid-fast bacilli with each chesty cough, and they won’t even be exposed to the disease. Even my future roommates’ future roommates probably… Read More…

Latent Tuberculosis

Posted by Graham McMahon • April 15th, 2011

The latest article in our Clinical Practice review series, Latent Tuberculosis Infection in the United States, comes from Drs. C. Robert Horsburgh, Jr. of Boston University School of Public Health and Eric J. Rubin of Harvard School of Public Health. There is no way to detect the presence of latent Mycobacterium tuberculosis in an individual… Read More…