{"id":11793,"date":"2011-09-14T16:00:02","date_gmt":"2011-09-14T20:00:02","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=11793"},"modified":"2011-09-14T18:48:19","modified_gmt":"2011-09-14T22:48:19","slug":"meta-analysis-finds-reduction-in-stent-thrombosis-with-everolimus-eluting-stents","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/09\/14\/meta-analysis-finds-reduction-in-stent-thrombosis-with-everolimus-eluting-stents\/","title":{"rendered":"Meta-Analysis Finds Reduction in Stent Thrombosis with Everolimus-Eluting Stents"},"content":{"rendered":"<p>Stent thrombosis and other complications are less likely to occur when everolimus-eluting stents (EES) are used, according to a <a href=\"http:\/\/content.onlinejacc.org\/cgi\/content\/abstract\/j.jacc.2011.06.049v1\">large meta-analysis<\/a> appearing in the <em>Journal of the American College of Cardiology<\/em>.<\/p>\n<p>Usman Baber and colleagues analyzed data from 13 trials that included 17,101 patients who were randomized to either EES or non-EES. They found significant reductions in stent thrombosis, MI, and target vessel revascularization with EES, but did not find a significant difference in cardiac mortality:<\/p>\n<ul>\n<li>Stent thrombosis: 0.7% for EES versus 1.5% for non-EES, RR 0.55, CI 0.38-0.78, p=0.001<\/li>\n<li>MI: 2.9% versus 3.9%, RR 0.78, CI 0.64-0.96; p=0.02<\/li>\n<li>Target vessel revascularization: 5.7% versus 7.7%, RR 0.77, CI 0.64-0.92, p=0.004<\/li>\n<li>Cardiac mortality: 1.6% versus 1.9%, RR 0.92, CI 0.74-1.16, p=0.38<\/li>\n<\/ul>\n<p>The authors state that their data &#8220;are the most comprehensive to date evaluating the comparative efficacy and safety of this novel second-generation DES to those of non-EES.&#8221; They point out that &#8220;any of the EES system components (metallic stent material, strut thickness, polymer, drug, elution properties, healing), or their combination could account for&#8221; the better performance of EES in their study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stent thrombosis and other complications are less likely to occur when an everolimus-eluting stent is used, according to a large new meta-analysis.<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[821,980,437],"class_list":["post-11793","post","type-post","status-publish","format-standard","hentry","category-interventional-cardiology","tag-drug-eluting-stents","tag-everolimus-eluting-stents","tag-stents"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/11793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=11793"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/11793\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=11793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=11793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=11793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}