{"id":11858,"date":"2011-09-19T09:36:05","date_gmt":"2011-09-19T13:36:05","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=prevention&#038;p=11858"},"modified":"2011-09-19T11:35:17","modified_gmt":"2011-09-19T15:35:17","slug":"doc-i-got-my-whole-genome-scanned-now-what","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/09\/19\/doc-i-got-my-whole-genome-scanned-now-what\/","title":{"rendered":"\u201cDoc, I Got My Whole Genome Scanned \u2013 Now What?\u201d"},"content":{"rendered":"<p>When Walmart announced that it would stock personal genetic kits, the FDA balked and Walmart held off. But that doesn\u2019t mean patients can\u2019t still order a personal whole <a href=\"http:\/\/www.washingtonpost.com\/wp-dyn\/content\/article\/2010\/01\/25\/AR2010012503038.html\" target=\"_blank\">genome scan online<\/a>.<\/p>\n<p>So what do you do if and when your patient shows you a commercially produced report of a personal whole genome scan? Do you treat the results as part of the medical record and manage accordingly? Or do you cite <a href=\"http:\/\/www.wired.com\/wiredscience\/2010\/06\/Sample-swaps-at-23andMe:-a-cautionary-tale\" target=\"_blank\">recently reported quality control problems<\/a> and lack of formal FDA regulation? Or do you refer the patient to a genetic counselor?<\/p>\n<p>With this week\u2019s issue of <em>Nature<\/em> reporting <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21909115?dopt=Abstract\" target=\"_blank\">another 16 new loci for hypertension<\/a>, the list of genotypes associated with a multitude of phenotypes \u2013 from height to Alzheimer\u2019s disease \u2013 <a href=\"http:\/\/www.genome.gov\/gwastudies\/\" target=\"_blank\">continues to burgeon<\/a>. Even though <a href=\"http:\/\/circ.ahajournals.org\/content\/122\/22\/2323.extract\" target=\"_blank\">genetic risk scores only modestly predict common complex diseases<\/a> (e.g. median <a href=\"http:\/\/hmg.oxfordjournals.org\/content\/18\/18\/3525.full\" target=\"_blank\">C statistics of 0.55-0.60<\/a> for coronary heart disease), this fact is often lost on the lay media and, in turn, the average public consumer.<\/p>\n<p>So if your next patient showed up in clinic with a genome scan report in hand, what would be your approach?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What do you do if your patient shows you a commercially produced report of a personal whole genome scan?<\/p>\n","protected":false},"author":484,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[270,273],"class_list":["post-11858","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-genetics","tag-genome-scanning"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/11858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/484"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=11858"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/11858\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=11858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=11858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=11858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}