{"id":1322,"date":"2009-11-02T11:34:06","date_gmt":"2009-11-02T16:34:06","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/genetic-testing-in%c2%a0unexplained-thrombosis%c2%a0-part-i\/"},"modified":"2011-07-19T17:44:07","modified_gmt":"2011-07-19T21:44:07","slug":"genetic-testing-in%c2%a0unexplained-thrombosis%c2%a0-part-i","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2009\/11\/02\/genetic-testing-in%c2%a0unexplained-thrombosis%c2%a0-part-i\/","title":{"rendered":"Genetic Testing in\u00a0Unexplained Thrombosis\u00a0\u2013 Part I"},"content":{"rendered":"<p><em>The case. (For an expert&#8217;s response, see <a href=\"http:\/\/cardioexchange.org\/blogPost?postId=180\">Part II<\/a>)<br \/>\n<\/em><br \/>\nA very healthy 44-year-old man who engaged in daily vigorous physical activity suddenly developed shortness of breath and pleuritic chest pain. He was quickly diagnosed with multiple pulmonary emboli. He was not overweight and had no recent history of long trips, injuries, periods of bed rest, or weight loss. Genetic testing revealed two polymorphisms that might be related to risk for thrombosis: prothrombin gene mutation (homozygous) and\u00a0PAI-I (plasminogen activator inhibitor type I) 4G\/4G polymorphism. No other tests revealed underlying causes of the thrombosis.<\/p>\n<ul>\n<li> How should the genetic test results affect his treatment?<\/li>\n<li> Should his children and siblings be tested? If they have these polymorphisms, what should they do?<\/li>\n<li> Was screening for these polymorphisms useful for this patient?<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The case. (For an expert&#8217;s response, see Part II) A very healthy 44-year-old man who engaged in daily vigorous physical activity suddenly developed shortness of breath and pleuritic chest pain. He was quickly diagnosed with multiple pulmonary emboli. He was not overweight and had no recent history of long trips, injuries, periods of bed rest, [&hellip;]<\/p>\n","protected":false},"author":211,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7,16],"tags":[],"class_list":["post-1322","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","category-vascular"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/211"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1322"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1322\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}