{"id":1357,"date":"2009-11-17T09:58:26","date_gmt":"2009-11-17T14:58:26","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/at-the-aha%c2%a0-a-challenge-to-uptitrate-losartan-in-heart-failure\/"},"modified":"2011-07-19T17:45:07","modified_gmt":"2011-07-19T21:45:07","slug":"at-the-aha%c2%a0-a-challenge-to-uptitrate-losartan-in-heart-failure","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2009\/11\/17\/at-the-aha%c2%a0-a-challenge-to-uptitrate-losartan-in-heart-failure\/","title":{"rendered":"At the AHA:\u00a0 A Challenge To Uptitrate Losartan in Heart Failure"},"content":{"rendered":"<p>During Tuesday morning&#8217;s Late-Breaking Clinical Trials session, investigators presented results of the HEALL trial.\u00a0 In this study, 3,846 patients with NYHA II-IV heart failure and LVEF \u226440% were randomized to losartan 150 mg versus 50 mg daily.\u00a0 Over a median follow-up period of 4.7 years, patients in the higher-dose losartan arm had a significantly reduce rate of hospital readmission and a non-significant reduction in mortality.\u00a0 The higher dose of losartan was also more likely than the lower dose to cause renal impairment, hypotension, and hyperkalemia, but not higher rates of discontinuing therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>During Tuesday morning&#8217;s Late-Breaking Clinical Trials session, investigators presented results of the HEALL trial.\u00a0 In this study, 3,846 patients with NYHA II-IV heart failure and LVEF \u226440% were randomized to losartan 150 mg versus 50 mg daily.\u00a0 Over a median follow-up period of 4.7 years, patients in the higher-dose losartan arm had a significantly reduce [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1357","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1357"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1357\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}