{"id":1358,"date":"2009-11-18T08:19:27","date_gmt":"2009-11-18T13:19:27","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/fda-weighs-in-on-combination-of-clopidogrel-and-omeprazole\/"},"modified":"2011-07-19T17:45:07","modified_gmt":"2011-07-19T21:45:07","slug":"fda-weighs-in-on-combination-of-clopidogrel-and-omeprazole","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2009\/11\/18\/fda-weighs-in-on-combination-of-clopidogrel-and-omeprazole\/","title":{"rendered":"FDA Weighs In On Combination of Clopidogrel and Omeprazole"},"content":{"rendered":"<p>Despite <a href=\"http:\/\/cardioexchange.org\/jwatch\/gastro\/content\/full\/2009\/1016\/1?searchTerm=clopidogrel\">recent data <\/a>suggesting no significant effect on outcomes when combining the use of clopidogrel and proton-pump inhibitors (PPIs), the issue <a href=\"http:\/\/cardioexchange.org\/jwatch\/cardiology\/content\/full\/2009\/901\/2\">remains contentious<\/a>.\u00a0 Today, the <a href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/DrugSafetyInformationforHeathcareProfessionals\/ucm190787.htm\">FDA updated clopidogrel&#8217;s label <\/a>to warn against its concurrent use with omeprazole.\u00a0 The agency reported that omeprazole can reduce clopidogrel&#8217;s effect by nearly half, according to new manufacturer-conducted studies.\u00a0 Concerns were also raised about esomeprazole, a component of omeprazole, although there were no official statements\u00a0made regarding PPIs other than omeprazole.<br \/>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite recent data suggesting no significant effect on outcomes when combining the use of clopidogrel and proton-pump inhibitors (PPIs), the issue remains contentious.\u00a0 Today, the FDA updated clopidogrel&#8217;s label to warn against its concurrent use with omeprazole.\u00a0 The agency reported that omeprazole can reduce clopidogrel&#8217;s effect by nearly half, according to new manufacturer-conducted studies.\u00a0 Concerns [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1358","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1358"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1358\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}