{"id":1395,"date":"2010-01-06T11:28:45","date_gmt":"2010-01-06T16:28:45","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/lpa-risk-and-relevance\/"},"modified":"2011-07-19T17:45:30","modified_gmt":"2011-07-19T21:45:30","slug":"lpa-risk-and-relevance","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/01\/06\/lpa-risk-and-relevance\/","title":{"rendered":"Lp(a): Risk and Relevance"},"content":{"rendered":"<p><a href=\"http:\/\/cardioexchange.org\/nejm\/content\/full\/361\/26\/2518\">Clarke et al.<\/a>\u00a0provide convincing evidence that plasma\u00a0Lp(a) lipoprotein is causally related to coronary artery disease. What\u2019s needed next?\u00a0First, we need to assess whether knowledge of Lp(a) lipoprotein concentrations improves\u00a0predictive discrimination over more traditional risk factors.\u00a0Second, we\u00a0need an intervention that selectively lowers plasma Lp(a) lipoprotein concentrations and a randomized clinical trial to\u00a0assess its efficacy. Of\u00a0currently FDA-approved medications, niacin is the only agent that effectively lowers plasma Lp(a) lipoprotein concentrations. Is it time for a randomized trial of niacin in patients with elevated plasma Lp(a) lipoprotein concentrations?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clarke et al.\u00a0provide convincing evidence that plasma\u00a0Lp(a) lipoprotein is causally related to coronary artery disease. What\u2019s needed next?\u00a0First, we need to assess whether knowledge of Lp(a) lipoprotein concentrations improves\u00a0predictive discrimination over more traditional risk factors.\u00a0Second, we\u00a0need an intervention that selectively lowers plasma Lp(a) lipoprotein concentrations and a randomized clinical trial to\u00a0assess its efficacy. Of\u00a0currently FDA-approved [&hellip;]<\/p>\n","protected":false},"author":190,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1395","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/190"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1395"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1395\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}