{"id":1453,"date":"2010-03-03T17:47:52","date_gmt":"2010-03-03T22:47:52","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/wednesday-march-3-drugs-for-shock-compared\/"},"modified":"2011-07-19T17:45:01","modified_gmt":"2011-07-19T21:45:01","slug":"wednesday-march-3-drugs-for-shock-compared","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/03\/03\/wednesday-march-3-drugs-for-shock-compared\/","title":{"rendered":"Wednesday, March 3: Drugs for Shock Compared"},"content":{"rendered":"<p>Norepinephrine and dopamine are both recommended as first line drugs for the treatment of shock. In <a href=\"http:\/\/content.nejm.org\/cgi\/content\/short\/362\/9\/779\">a report by De Backer et al in the <em>New England Journal of Medicine<\/em><\/a>, 1,679 shock patients were enrolled in the SOAP II trial and randomized to initial vasopressor therapy with one of the drugs. At 28 days there was no significant difference in mortality between the two groups (52.5% in the dopamine group versus 48.5% in the norepinephrine group). However, patients treated with dopamine had more arrhythmic events, and dopamine was associated with increased mortality in the subgroup of patients with cardiogenic shock. In&nbsp;<a href=\"http:\/\/content.nejm.org\/cgi\/content\/short\/362\/9\/841\">an accompanying editorial<\/a>, &nbsp;Jerrold Levy writes that the study should &#8220;put an end to the outdated view that the use of norepinephrine increases the risk of death.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Norepinephrine and dopamine are both recommended as first line drugs for the treatment of shock. In a report by De Backer et al in the New England Journal of Medicine, 1,679 shock patients were enrolled in the SOAP II trial and randomized to initial vasopressor therapy with one of the drugs. At 28 days there [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1453","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1453"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1453\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}