{"id":1464,"date":"2010-03-12T14:58:32","date_gmt":"2010-03-12T19:58:32","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/friday-march-12-plavix-gets-a-black-box\/"},"modified":"2011-07-19T17:45:01","modified_gmt":"2011-07-19T21:45:01","slug":"friday-march-12-plavix-gets-a-black-box","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/03\/12\/friday-march-12-plavix-gets-a-black-box\/","title":{"rendered":"Friday March 12: Plavix Gets a Black Box"},"content":{"rendered":"<p>The FDA has added a black box warning to the Plavix (clopidogrel) label. The black box warns about people &#8220;who do not effectively metabolize the drug&#8230; and therefore may not receive the full benefits of the drug.&#8221; The warning also informs healthcare professionals about tests that can identify the underlying genetic differences in clopidogrel metabolism and advises them &#8220;to consider use of other anti-platelet medications or alternative dosing strategies for Plavix in patients identified as poor metabolizers.&#8221; <a href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm203888.htm#ds\">Click here for the full FDA communication.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The FDA has added a black box warning to the Plavix (clopidogrel) label. The black box warns about people &#8220;who do not effectively metabolize the drug&#8230; and therefore may not receive the full benefits of the drug.&#8221; The warning also informs healthcare professionals about tests that can identify the underlying genetic differences in clopidogrel metabolism [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1464","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1464"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1464\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}