{"id":1530,"date":"2010-05-14T12:59:15","date_gmt":"2010-05-14T16:59:15","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/%e2%80%a2time-window-for-tpa-in-stroke-extended-to-4-5-hours\/"},"modified":"2011-07-19T17:44:58","modified_gmt":"2011-07-19T21:44:58","slug":"time-window-for-tpa-in-stroke-extended-to-4-5-hours","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/05\/14\/time-window-for-tpa-in-stroke-extended-to-4-5-hours\/","title":{"rendered":"Time Window for TPA in Stroke Extended to 4.5 Hours"},"content":{"rendered":"<p><strong>Time Window for TPA in Stroke Extended to 4.5 Hours:<\/strong> <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2810%2960491-6\/fulltext\">A new pooled analysis in the <em>Lancet<\/em><\/a> provides evidence that rt-PA may be beneficial when given up to 4.5 hours after stroke onset. Kennedy Lees and colleagues added data from 2 recent trials (ECASS III and EPITHET) to 6 earlier trials to re-examine the effect of time to treatment. As in previous analyses, earlier time to treatment was associated with better outcomes. No benefits were observed when rt-PA was given after 4.5 hours. In <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2810%2960634-4\/fulltext\">an accompanying comment<\/a>, Jeffrey Saver and Steven Levine write that the findings &#8220;mandate a renewed commitment by clinicians and policy makers to foster very early intervention.&nbsp;We need to increase the proportion of patients arriving at hospital in the first, golden hour after ischaemia onset&#8230;. In thrombolytic stroke therapy, sooner is better than later, much better.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Time Window for TPA in Stroke Extended to 4.5 Hours: A new pooled analysis in the Lancet provides evidence that rt-PA may be beneficial when given up to 4.5 hours after stroke onset. Kennedy Lees and colleagues added data from 2 recent trials (ECASS III and EPITHET) to 6 earlier trials to re-examine the effect [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1530","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1530"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1530\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}