{"id":1539,"date":"2010-05-27T12:45:35","date_gmt":"2010-05-27T16:45:35","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/should-we-aim-for-fame\/"},"modified":"2011-07-19T17:44:17","modified_gmt":"2011-07-19T21:44:17","slug":"should-we-aim-for-fame","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/05\/27\/should-we-aim-for-fame\/","title":{"rendered":"Should We Aim For FAME?"},"content":{"rendered":"<p>In patients with multivessel CAD suitable for PCI, what&#8217;s the best way to determine whether\u00a0a stent should be placed? Researchers in the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation\u00a0<a href=\"http:\/\/content.nejm.org\/cgi\/reprint\/360\/3\/213.pdf\">(FAME) study<\/a> compared outcomes when PCI with drug-eluting stents was guided by angiography alone versus angiography plus\u00a0measurement of FFR.\u00a0<a href=\"http:\/\/content.onlinejacc.org\/cgi\/content\/abstract\/j.jacc.2010.04.012v1\">At 2 years of follow-up<\/a>, routine measurement of FFR significantly reduced mortality and myocardial infarction (by 35%) when compared with angiography-guided PCI.<\/p>\n<p>Still, I am skeptical that the FAME results are applicable to the \u201creal world.\u201d Although FFR measurements were attainable quickly in &gt;90% of subjects, I believe that some\u00a0\u2014 maybe even many\u00a0\u2014 interventionalists are uncomfortable and\/or inexperienced in doing them, thereby making the results difficult to trust.<\/p>\n<p>Are you convinced that the addition of FFR to angiography prevents unnecessary stenting (and improves outcomes)?\u00a0\u00a0 If so, why is it so seldom used?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In patients with multivessel CAD suitable for PCI, what&#8217;s the best way to determine whether\u00a0a stent should be placed? Researchers in the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation\u00a0(FAME) study compared outcomes when PCI with drug-eluting stents was guided by angiography alone versus angiography plus\u00a0measurement of FFR.\u00a0At 2 years of follow-up, routine measurement of [&hellip;]<\/p>\n","protected":false},"author":190,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,9],"tags":[],"class_list":["post-1539","post","type-post","status-publish","format-standard","hentry","category-general","category-interventional-cardiology"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/190"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1539"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1539\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}