{"id":15607,"date":"2012-01-25T19:06:57","date_gmt":"2012-01-26T00:06:57","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=15607"},"modified":"2012-01-25T19:06:57","modified_gmt":"2012-01-26T00:06:57","slug":"huge-study-finds-risk-factors-do-in-fact-predict-risk","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/01\/25\/huge-study-finds-risk-factors-do-in-fact-predict-risk\/","title":{"rendered":"Huge Study Finds Risk Factors Do In Fact Predict Risk"},"content":{"rendered":"<p>An enormous new meta-analysis confirms the important role that risk factors play over a lifetime in the development of cardiovascular disease.\u00a0In a paper\u00a0<a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1012848\">published in the\u00a0<em>New England Journal of Medicine<\/em><\/a>, Jarett Berry and colleagues report on the meta-analysis from the Cardiovascular Lifetime Risk Pooling Project, which contains\u00a0data from 18 epidemiological studies including more than one-quarter million people whose risk factors &#8212; blood pressure, cholesterol level, smoking status, and diabetes status &#8212;\u00a0were measured every decade from 45 to 75 years of age.<\/p>\n<p>At age 55, compared to people with two or more risk factors, people with an optimal risk factor profile had a greatly reduced risk of death from CV disease \u00a0or CHD through the age of 80:<\/p>\n<p>Death from CV disease (two or more risk factors vs. optimal risk factor profile):<\/p>\n<ul>\n<li>men:\u00a029.6% vs. 4.7%<\/li>\n<li>women: 20.5% vs. 6.4%<\/li>\n<\/ul>\n<div>Fatal CHD or nonfatal MI:<\/div>\n<ul>\n<li>men: 37.5% vs. 3.6%<\/li>\n<li>women: 18.3% vs. &lt;1%<\/li>\n<\/ul>\n<p>Fatal or nonfatal stroke:<\/p>\n<ul>\n<li>men: 8.3% vs. 2.3%<\/li>\n<li>women: 10.7% vs. 5.3%<\/li>\n<\/ul>\n<p>\u201cIn general, previous studies have only looked at CVD risk factors across one specific age or gender in white populations,\u201d said Donald M. Lloyd-Jones, principal investigator of the study, in an NHLBI press release. \u201cWe analyzed an enormous pool of available data, which allowed for a more precise estimate of lifetime CVD risks across the age, sex, race, and risk factor spectrum.\u201d<\/p>\n<p>The authors identified three major findings in their study:<\/p>\n<ol>\n<li>The results &#8220;strongly reinforce the influence of traditional risk factors on the lifetime risk of cardiovascular disease. Even a relatively low burden of these risk factors was associated with significant increases in the long-term risk of cardiovascular disease, and the absence of traditional risk factors was associated with a very low lifetime risk.&#8221;<\/li>\n<li>The impact of the risk factors &#8220;remained remarkably consistent across birth cohorts.&#8221;<\/li>\n<li>Risk factors had the same influence on lifetime risk in blacks and whites.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>An enormous new meta-analysis confirms the important role that risk factors play over a lifetime in the development of cardiovascular disease.\u00a0In a paper\u00a0published in the\u00a0New England Journal of Medicine, Jarett Berry and colleagues report on the meta-analysis from the Cardiovascular Lifetime Risk Pooling Project, which contains\u00a0data from 18 epidemiological studies including more than one-quarter million [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[1126,271],"class_list":["post-15607","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-lifetime-risk","tag-risk-factors"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/15607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=15607"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/15607\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=15607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=15607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=15607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}