{"id":1561,"date":"2010-06-22T15:21:39","date_gmt":"2010-06-22T19:21:39","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/%e2%80%a2-aggrenox-fails-to-beat-aspirin-in-japanese-study%e2%80%a2-livalo-now-available-in-the-u-s-%e2%80%a2-new-york-times-spotlights-icds-with-benefits\/"},"modified":"2011-07-19T17:44:56","modified_gmt":"2011-07-19T21:44:56","slug":"%e2%80%a2-aggrenox-fails-to-beat-aspirin-in-japanese-study%e2%80%a2-livalo-now-available-in-the-u-s-%e2%80%a2-new-york-times-spotlights-icds-with-benefits","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/06\/22\/%e2%80%a2-aggrenox-fails-to-beat-aspirin-in-japanese-study%e2%80%a2-livalo-now-available-in-the-u-s-%e2%80%a2-new-york-times-spotlights-icds-with-benefits\/","title":{"rendered":"\u2022 Aggrenox Fails to Beat Aspirin in Japanese Study<br \/>\u2022 Livalo Now Available in the U.S.<br \/> \u2022 New York Times Spotlights ICDs with Benefits"},"content":{"rendered":"<p><strong>Aggrenox Fails to Beat Aspirin in Japanese Study:<\/strong>&nbsp;Aggrenox, the combination of extended-release dipyridamole and aspirin, is indicated for the reduction of subsequent stroke in patients who have had a TIA or ischemic stroke. But results from <a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT00311402?sect=Xafb76015\">JASAP (Japanese Aggrenox Stroke Prevention vs. Aspirin Programme)<\/a>, which compared Aggrenox to aspirin in 1294 patients, found that Aggrenox failed to cause a significant reduction in recurrent stroke; in fact, there was a trend toward more strokes in the Aggrenox group than in the aspirin group (45 vs. 32, P=0.097). <\/p>\n<p>The manufacturer of Aggrenox, Boehringer Ingelheim, has not publicized the results, which&nbsp;were first received on February 16, 2010 and posted on&nbsp;<a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT00311402?sect=Xfed98b76015#outcome10\">ClinicalTrials.gov<\/a>&nbsp;in March. News of JASAP was first reported on <a href=\"http:\/\/www.pharmalot.com\/2010\/06\/boehringer-heart-drug-fails-to-beat-aspirin\/\">Pharmalot<\/a>. Boehringer Ingelheim provided Pharmalot with <a href=\"http:\/\/freepdfhosting.com\/0f058addab.pdf\">a statement<\/a>: &#8220;Because neither non-inferiority nor superiority of either treatment could be demonstrated, we cannot draw conclusions from this study about the relative efficacy of either agent.&#8221; Aggrenox&#8217;s initial approval was based on the results of the <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8981292\">second European Stroke Prevention Study<\/a>. <\/p>\n<p><strong>Livalo Now Available in the U.S.:<\/strong> Livalo (pitavastatin) is now available in the United States, according to the drug&#8217;s manufacturer, Eli Lilly. However, <a href=\"http:\/\/www.pharmalot.com\/2010\/06\/eli-lilly-innovation-and-another-cholesterol-pill\/\">as noted on Pharmalot<\/a>, Wall Street analysts question whether the drug will find a large commercial market.<\/p>\n<p><strong><em>New York Times<\/em> Spotlights&nbsp;ICDs with Benefits:<\/strong> A <a href=\"http:\/\/www.nytimes.com\/2010\/06\/22\/health\/22heart.html?src=twt&amp;twt=nytimeshealth&amp;pagewanted=all\">feature article in the <em>New York Times<\/em><\/a> by Gina Kolata provides a mostly sunny view of ICDs with remote monitoring features. Although the article quotes Lynne Warner Stevenson as saying that &#8220;information overload is a very serious problem,&#8221; most of the comments in the story, including others by Stevenson, Leslie Saxon, and Richard Page, take a positive view of the devices. Page calls the new technology &#8220;potentially transformative.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aggrenox Fails to Beat Aspirin in Japanese Study:&nbsp;Aggrenox, the combination of extended-release dipyridamole and aspirin, is indicated for the reduction of subsequent stroke in patients who have had a TIA or ischemic stroke. But results from JASAP (Japanese Aggrenox Stroke Prevention vs. Aspirin Programme), which compared Aggrenox to aspirin in 1294 patients, found that Aggrenox [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1561","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=1561"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/1561\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=1561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=1561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=1561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}