{"id":15653,"date":"2012-01-26T15:50:42","date_gmt":"2012-01-26T20:50:42","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=15653"},"modified":"2012-01-26T15:50:42","modified_gmt":"2012-01-26T20:50:42","slug":"nhlbi-launches-two-large-cardiac-arrest-treatment-trials","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/01\/26\/nhlbi-launches-two-large-cardiac-arrest-treatment-trials\/","title":{"rendered":"NHLBI Launches Two Large Cardiac Arrest Treatment Trials"},"content":{"rendered":"<p><a href=\"http:\/\/public.nhlbi.nih.gov\/newsroom\/home\/GetPressRelease.aspx?id=2826\">The NHLBI today announced<\/a>\u00a0the launch of two large clinical trials evaluating treatments for out-of-hospital cardiac arrest.<\/p>\n<p><a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01372748?term=continuous+chest+compressions&amp;rank=3\">The Continuous Chest Compressions (CCC)\u00a0<\/a>trial\u00a0will randomize 23,600 people with out-of-hospital cardiac arrest to either standard CPR or continuous chest compressions, both delivered by paramedics or fire fighters. In recent years, studies published in\u00a0the\u00a0<a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa0908993\"><em>New England Journal of Medicine<\/em><\/a>,\u00a0\u00a0<em><a href=\"http:\/\/jama.ama-assn.org\/content\/304\/13\/1447.abstract?maxtoshow=&amp;hits=10&amp;RESULTFORMAT=&amp;fulltext=Bentley+Bobrow&amp;searchid=1&amp;FIRSTINDEX=0&amp;resourcetype=HWCIT\">JAMA<\/a>,<\/em>\u00a0and the\u00a0<em><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(10)61454-7\/abstract\">Lancet<\/a>\u00a0<\/em>have provided evidence that continuous chest compressions may be preferable to traditional CPR. Graham Nichol is the principal investigator.<\/p>\n<p>\u201cThe CCC trial will help to determine if continuous compressions is equal to or better than standard professional CPR when paramedics, who are better able to provide assisted breathing than bystanders, intervene,&#8221; said Nichol, in an NHLBI press release.<\/p>\n<p><a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01401647\">The Amiodarone, Lidocaine, or Neither [Placebo] for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia study (ALPS)<\/a>\u00a0will randomize 3000 people with shock-resistant\u00a0VF\u00a0to amiodarone, lidocaine, or placebo. Although amiodarone and lidocaine are often given when shock treatment fails in\u00a0VF\u00a0patients, a beneficial effect of the drugs has never been demonstrated in this setting.\u00a0Peter Kudenchuk is the principal investigator.<\/p>\n<p>Both\u00a0trials are part of the NIH-supported Resuscitation Outcomes Consortium (ROC), which the NIH describes as &#8220;the first large-scale clinical research network in the world designed to study, improve, and standardize how EMS teams deliver very early, pre-hospital interventions to improve patient survival after cardiac arrest or trauma.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The NHLBI today announced\u00a0the launch of two large clinical trials evaluating treatments for out-of-hospital cardiac arrest. The Continuous Chest Compressions (CCC)\u00a0trial\u00a0will randomize 23,600 people with out-of-hospital cardiac arrest to either standard CPR or continuous chest compressions, both delivered by paramedics or fire fighters. In recent years, studies published in\u00a0the\u00a0New England Journal of Medicine,\u00a0\u00a0JAMA,\u00a0and the\u00a0Lancet\u00a0have provided [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[317,316,242],"class_list":["post-15653","post","type-post","status-publish","format-standard","hentry","category-general","tag-cardiac-arrest","tag-compression-only-cpr","tag-resuscitation"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/15653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=15653"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/15653\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=15653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=15653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=15653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}