The FDA is warning again about interactions between protease inhibitors and certain statins that can lead to rhabdomyolysis. Protease inhibitors are used to treat HIV and hepatitis C.<\/p>\n
In a safety communication, the agency published a list of statins that should either be avoided or whose dosing levels should be limited when coadministered with protease inhibitors. Atorvastatin, lovastatin, rosuvastatin, and simvastatin are either listed as contraindicated or have had limits put on dosages.<\/p>\n
In particular, lovastatin and simvastatin exposures can increase beyond 10-fold when used with protease inhibitors, and rosuvastatin exposure can increase up to 3-fold, according to the FDA.<\/p>\n
Earlier this week, the agency announced several changes to statin labels, including a warning to avoid lovastatin in combination with HIV protease inhibitors.<\/p>\n
This post is reprinted from <\/em>Physician\u2019s First Watch<\/a>, a part of the <\/em>Journal Watch<\/a> family. <\/em>PFW is a free daily alert on current news that affects your practice \u2014 from medical journals, government agencies, scientific conferences, and major media reports.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":" The FDA is warning again about interactions between protease inhibitors and certain statins that can lead to rhabdomyolysis. Protease inhibitors are used to treat HIV and hepatitis C. In a safety communication, the agency published a list of statins that should either be avoided or whose dosing levels should be limited when coadministered with protease […]<\/p>\n","protected":false},"author":346,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[1159,584],"class_list":["post-27040","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-drug-interactions","tag-statins"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/27040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/346"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=27040"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/27040\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=27040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=27040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=27040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}