{"id":2879,"date":"2010-08-31T06:12:08","date_gmt":"2010-08-31T10:12:08","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=2879"},"modified":"2011-07-19T17:44:52","modified_gmt":"2011-07-19T21:44:52","slug":"no-benefits-for-low-dose-heparin-over-standard-heparin-in-futuraoasis-8","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/08\/31\/no-benefits-for-low-dose-heparin-over-standard-heparin-in-futuraoasis-8\/","title":{"rendered":"No Benefits for Low-Dose Heparin Over Standard Heparin in FUTURA\/OASIS-8"},"content":{"rendered":"<p>FUTURA (Fondaparinux Trial With Unfractionated Heparin During  Revascularization   in Acute Coronary Syndromes)\/OASIS-8 is the first  trial to compare low-dose unfractionated heparin with conventional  heparin dosing in PCI patients receiving fondaparinux. Sanjit Jolly and  colleagues randomized 2026 non-STEMI high-risk patients undergoing PCI  within 72 hours to either low-dose unfractionated heparin or a standard  dose of heparin adjusted by activated clotting time (ACT), in addition to fondaparinux. The results  were presented at the ESC in Stockholm and <a href=\"http:\/\/jama.ama-assn.org\/cgi\/content\/full\/jama.2010.1320\">published simultaneously in <em> JAMA<\/em><\/a>.<\/p>\n<p>The primary endpoint \u2014 a composite of major bleeding, minor  bleeding, or major vascular access-site complications in the 48 hours  after PCI \u2014 occurred in 4.7% of patients in the low-dose group compared with 5.8% of the conventional-dose group. This difference  did not achieve statistical significance. The researchers also observed a  nonsignificant increase in the low-dose group in the composite  secondary endpoint of periprocedural major bleeding or 30-day death, MI, or target vessel revascularization.<\/p>\n<p>The authors conclude: &#8220;The finding that adding ACT-guided  unfractionated heparin to   fondaparinux while treating patients with  acute coronary syndromes does   not increase major bleeding is important  in the context of modern PCI   practice&#8230;. These findings support  using the currently recommended standard   ACT-guided dose of  unfractionated heparin when performing PCI in   patients with non-ST  segment elevation acute coronary syndromes who are   treated with  fondaparinux.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>FUTURA (Fondaparinux Trial With Unfractionated Heparin During Revascularization in Acute Coronary Syndromes)\/OASIS-8 is the first trial to compare low-dose unfractionated heparin with conventional heparin dosing in PCI patients receiving fondaparinux. Sanjit Jolly and colleagues randomized 2026 non-STEMI high-risk patients undergoing PCI within 72 hours to either low-dose unfractionated heparin or a standard dose of heparin [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,9],"tags":[347,348,350,349],"class_list":["post-2879","post","type-post","status-publish","format-standard","hentry","category-general","category-interventional-cardiology","tag-fondaparinux","tag-heparin","tag-low-dose-heparin","tag-unfractionated-heparin"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/2879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=2879"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/2879\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=2879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=2879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=2879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}