{"id":29073,"date":"2012-05-17T09:57:50","date_gmt":"2012-05-17T13:57:50","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=29073"},"modified":"2012-05-17T09:58:06","modified_gmt":"2012-05-17T13:58:06","slug":"study-casts-doubt-on-protective-effects-of-raising-hdl-cholesterol","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/05\/17\/study-casts-doubt-on-protective-effects-of-raising-hdl-cholesterol\/","title":{"rendered":"Study Casts Doubt on Protective Effects of Raising HDL Cholesterol"},"content":{"rendered":"<p>A genetics-based analysis finds that raising HDL will not necessarily lower risk for myocardial infarction. Reporting in the Lancet, researchers describe a two-pronged approach.<\/p>\n<p>First, they searched for the presence of a specific allele (LIPG Asn396Ser, associated with higher HDL levels in carriers) in a large cohort of subjects with and without MI. The allele&#8217;s presence should have lowered MI risk by about 15%, but no such association was found.<\/p>\n<p>Similarly, testing for the presence of an array of HDL-raising gene variants (and assigning a score on the basis of the number of variants in each subject) failed to find an association of lower risk with higher scores.<\/p>\n<p>The authors conclude that raising HDL, whether with lifestyle interventions or drugs, &#8220;cannot be assumed ipso facto to lead to a corresponding benefit with respect to &#8230; myocardial infarction.&#8221;<\/p>\n<p><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2812%2960312-2\/fulltext\">Lancet article<\/a> (Free abstract)<\/p>\n<p><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2812%2960481-4\/fulltext\">Lancet comment<\/a> (Subscription required)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A genetics-based analysis finds that raising HDL will not necessarily lower risk for myocardial infarction. Reporting in the Lancet, researchers describe a two-pronged approach. First, they searched for the presence of a specific allele (LIPG Asn396Ser, associated with higher HDL levels in carriers) in a large cohort of subjects with and without MI. The allele&#8217;s [&hellip;]<\/p>\n","protected":false},"author":346,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[210,209,214],"class_list":["post-29073","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-cholesterol","tag-hdl","tag-ldl"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/29073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/346"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=29073"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/29073\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=29073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=29073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=29073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}