{"id":30382,"date":"2012-07-12T09:46:25","date_gmt":"2012-07-12T13:46:25","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=30382"},"modified":"2012-07-12T09:46:25","modified_gmt":"2012-07-12T13:46:25","slug":"clopidogrel-ppi-interaction-deemed-clinically-unimportant","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/07\/12\/clopidogrel-ppi-interaction-deemed-clinically-unimportant\/","title":{"rendered":"Clopidogrel\u2013PPI Interaction Deemed &#8216;Clinically Unimportant&#8217;"},"content":{"rendered":"<p>The interaction between clopidogrel and proton-pump inhibitors is &#8220;clinically unimportant,&#8221; <a href=\"http:\/\/www.bmj.com\/content\/345\/bmj.e4388\">researchers conclude in <em>BMJ<\/em><\/a>.<\/p>\n<p>The researchers used U.K. registries to study some 24,000 acute coronary syndrome patients who were prescribed both aspirin and clopidogrel; half the patients also received a PPI at some point during the study.<\/p>\n<p>After nearly a year&#8217;s follow-up, incident MI or all-cause mortality had occurred significantly more often during PPI use than nonuse (11% vs. 8% of patients). However, a self-controlled case series analysis \u2014 performed to eliminate confounding from differences between patients \u2014 showed no significant association between PPI use and MI (rate ratio, 0.75).<\/p>\n<p>These findings suggest that the PPI\u2013clopidogrel interaction &#8220;does not result in clinical harm,&#8221; the researchers write. They add that concomitant use of PPIs with clopidogrel and aspirin &#8220;is well proved to prevent harm through gastrointestinal bleeding, and we should continue to consider proton-pump inhibitors as important prophylactic drugs in patients at high risk.&#8221;<\/p>\n<p>Click <a href=\"http:\/\/www.bmj.com\/content\/345\/bmj.e4558\">here <\/a>to read the editorial that accompanied the study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The interaction between clopidogrel and proton-pump inhibitors is &#8220;clinically unimportant,&#8221; researchers conclude in BMJ. The researchers used U.K. registries to study some 24,000 acute coronary syndrome patients who were prescribed both aspirin and clopidogrel; half the patients also received a PPI at some point during the study. After nearly a year&#8217;s follow-up, incident MI or [&hellip;]<\/p>\n","protected":false},"author":577,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-30382","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/30382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/577"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=30382"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/30382\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=30382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=30382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=30382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}