{"id":30425,"date":"2012-07-13T09:08:50","date_gmt":"2012-07-13T13:08:50","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=30425"},"modified":"2012-07-13T09:08:50","modified_gmt":"2012-07-13T13:08:50","slug":"meta-analysis-ace-inhibitors-associated-with-lower-pneumonia-risk","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/07\/13\/meta-analysis-ace-inhibitors-associated-with-lower-pneumonia-risk\/","title":{"rendered":"Meta-Analysis: ACE Inhibitors Associated with Lower Pneumonia Risk"},"content":{"rendered":"<p>Angiotensin-converting\u2013enzyme inhibitors may offer some protection against pneumonia, according to <a title=\"ACE_BMJ\" href=\"http:\/\/www.bmj.com\/content\/345\/bmj.e4260.pdf%2Bhtml\" target=\"_blank\">a\u00a0<em>BMJ<\/em>\u00a0meta-analysis<\/a>. An editorialist isn&#8217;t so sure.<\/p>\n<p>Researchers looked at almost 40 studies \u2014 including cohort studies, case-control studies, and randomized trials \u2014 that reported pneumonia outcomes after use of ACE inhibitors, angiotensin-receptor blockers, and control treatments. The data revealed that <a title=\"ACE_JW\" href=\"http:\/\/infectious-diseases.jwatch.org\/cgi\/content\/full\/2004\/524\/11?q=pfw\" target=\"_blank\">ACE inhibitors<\/a> conferred a roughly 30% decrease in risk for pneumonia, when compared with ARBs or control treatments. The effect was particularly pronounced in Asian patients.<\/p>\n<p>The authors speculate that the cough often associated with ACE inhibitors may actually play a part in the protective effect by clearing respiratory tract secretions.<\/p>\n<p><a title=\"ACE_BMJ_editorial\" href=\"http:\/\/www.bmj.com\/content\/345\/bmj.e4566\" target=\"_blank\">An editorialist<\/a> finds it &#8220;difficult to agree&#8221; with the authors&#8217; enthusiasm. She calls for more studies &#8220;before we advise patients to put up with their cough because it may prevent them from getting pneumonia.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Angiotensin-converting\u2013enzyme inhibitors may offer some protection against pneumonia, according to a\u00a0BMJ\u00a0meta-analysis. An editorialist isn&#8217;t so sure. Researchers looked at almost 40 studies \u2014 including cohort studies, case-control studies, and randomized trials \u2014 that reported pneumonia outcomes after use of ACE inhibitors, angiotensin-receptor blockers, and control treatments. The data revealed that ACE inhibitors conferred a roughly [&hellip;]<\/p>\n","protected":false},"author":494,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[512,929],"class_list":["post-30425","post","type-post","status-publish","format-standard","hentry","category-general","tag-ace-inhibitors","tag-pneumonia"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/30425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/494"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=30425"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/30425\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=30425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=30425"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=30425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}