{"id":31143,"date":"2012-08-20T15:53:24","date_gmt":"2012-08-20T19:53:24","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=31143"},"modified":"2012-08-20T15:53:24","modified_gmt":"2012-08-20T19:53:24","slug":"tnf-inhibitors-linked-to-reduction-in-mi-for-psoriasis-patients","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/08\/20\/tnf-inhibitors-linked-to-reduction-in-mi-for-psoriasis-patients\/","title":{"rendered":"TNF Inhibitors Linked to Reduction in MI for Psoriasis Patients"},"content":{"rendered":"<p>Psoriasis patients who take TNF inhibitors have a significant reduction in the risk for myocardial infarction (MI), according to <a title=\"ArchDermatol_TNF_MI\" href=\"http:\/\/archderm.jamanetwork.com\/article.aspx?articleid=1352160\" target=\"_blank\">a retrospective cohort study published in<em>\u00a0Archives of Dermatology<\/em><\/a>. Although previous research suggested that the anti-inflammatory effects of methotrexate, an older therapy, may be beneficial in this population, the cardiovascular effects of TNF inhibitors had not been well studied.<\/p>\n<p>Researchers identified 8845 patients who were diagnosed with psoriasis or psoriatric arthritis within the Kaiser Permanente Southern California health plan. After a median of 4.3 years of observation, the overall rate of MI was 5.21 per 1000 patient-years.<\/p>\n<ul>\n<li>In the 1673 patients who received a TNF inhibitor (etanercept, infliximab, or adalimumab), the MI rate was 3.05 per 1000 patient-years.<\/li>\n<li>In the 2097 patients who received oral therapy or phototherapy, the MI rate was 3.85 per 1000 patient-years.<\/li>\n<li>In the 5075 patients who received topical therapy, the MI rate was 6.73 per 1000 patient-years.<\/li>\n<\/ul>\n<p>TNF inhibitors and oral therapy\/phototherapy were each superior to topical therapy, but the difference between TNF inhibitors and oral therapy\/phototherapy was not significant. Compared with topical agents, TNF inhibitors and oral agents\/phototherapy had hazard ratios (adjusted for other risk factors) of 0.50 and 0.54, respectively.<\/p>\n<p>The authors write, &#8220;This is the first large scale retrospective cohort study to show that the use of TNF inhibitors for psoriasis is associated with a clinically and statistically significant reduction in MI risk and incident rate compared with psoriatic patients treated with topical agents.&#8221; However, they note that &#8220;prospective studies are needed and warranted to determine whether the use of TNF inhibitors may reduce the risk of major adverse cardiovascular events in patients with systemic inflammatory conditions.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psoriasis patients who take TNF inhibitors have a significant reduction in the risk for myocardial infarction (MI), according to a retrospective cohort study published in\u00a0Archives of Dermatology. Although previous research suggested that the anti-inflammatory effects of methotrexate, an older therapy, may be beneficial in this population, the cardiovascular effects of TNF inhibitors had not been [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[1415,1413,486,1414,1314,1411,1412],"class_list":["post-31143","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-adalimumab","tag-etanercept","tag-inflammation","tag-infliximab","tag-myocardial-infarction","tag-psoriasis","tag-tnf-inhibitors"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=31143"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31143\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=31143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=31143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=31143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}