{"id":31544,"date":"2012-09-04T09:27:41","date_gmt":"2012-09-04T13:27:41","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=31544"},"modified":"2012-09-04T09:27:41","modified_gmt":"2012-09-04T13:27:41","slug":"fda-warns-against-using-revatio-in-kids-with-pulmonary-hypertension","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/09\/04\/fda-warns-against-using-revatio-in-kids-with-pulmonary-hypertension\/","title":{"rendered":"FDA Warns Against Using Revatio in Kids with Pulmonary Hypertension"},"content":{"rendered":"<p>Revatio (sildenafil) should not be prescribed to children and adolescents with pulmonary arterial hypertension, according to an <a href=\"http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm317743.htm\">FDA MedWatch alert<\/a>.<\/p>\n<p>The warning is based on the results of a <a href=\"http:\/\/circ.ahajournals.org\/content\/125\/2\/324.abstract\">trial published in <em>Circulation<\/em><\/a> that showed increased mortality at medium and high doses of Revatio, compared with low-dose treatment, among patients aged 1 to 17 years. Low-dose Revatio did not improve exercise capacity.<\/p>\n<p>The FDA notes that Revatio has never been approved to treat pulmonary arterial hypertension in children.<\/p>\n<p><em>Reprinted with permission from<\/em> <a href=\"http:\/\/firstwatch.jwatch.org\">Physician&#8217;s First Watch<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Revatio (sildenafil) should not be prescribed to children and adolescents with pulmonary arterial hypertension, according to an FDA MedWatch alert. The warning is based on the results of a trial published in Circulation that showed increased mortality at medium and high doses of Revatio, compared with low-dose treatment, among patients aged 1 to 17 years. [&hellip;]<\/p>\n","protected":false},"author":494,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,16],"tags":[],"class_list":["post-31544","post","type-post","status-publish","format-standard","hentry","category-pediatric-cardiology","category-vascular"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/494"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=31544"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31544\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=31544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=31544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=31544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}