{"id":31822,"date":"2012-09-13T18:30:16","date_gmt":"2012-09-13T22:30:16","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=31822"},"modified":"2012-09-13T19:28:12","modified_gmt":"2012-09-13T23:28:12","slug":"meta-analysis-links-stress-at-work-and-heart-disease","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/09\/13\/meta-analysis-links-stress-at-work-and-heart-disease\/","title":{"rendered":"Meta-Analysis Links Stress at Work and Heart Disease"},"content":{"rendered":"<p>A <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2812%2960994-5\/abstract\">new study in the <em>Lancet <\/em><\/a>provides the best evidence yet that work-related stress and, in particular, job strain &#8212; &#8220;the combination of high job demands and low control at work&#8221; &#8212; plays a small but important role in causing heart disease. In order to address the limitations of previous studies on this topic, including a publication bias which might exaggerate the effect, European investigators performed a large collaborative meta-analysis of published and unpublished studies.<\/p>\n<p>The IPD-Work (individual-participant-data meta-analysis in working populations) consortium found that 15% of nearly 200,000 individuals reported having job strain. With a mean follow-up of 7.5 years, job strain was significantly associated with increased risk for heart disease. The effect was higher in published studies, though it still achieved significance in the unpublished studies:<\/p>\n<ul>\n<li>Overall hazard ratio (HR) for job strain: 1.23,CI 1.10\u20131.37<\/li>\n<li>HR in published studies: 1.43, CI 1.15\u22121.77<\/li>\n<li>HR in unpublished studies: 1.16, CI 1.02\u22121.32<\/li>\n<\/ul>\n<p>The investigators calculated that the population attributable risk for job strain was 3.4%, which, they noted, was substantially lower than the major risk factors of smoking, obesity, and physical inactivity.<\/p>\n<p>&#8220;Our findings suggest that job strain is associated with a small, but consistent, increased risk of an incident event of cardiovascular heart disease,&#8221; they concluded.<\/p>\n<p>In <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2812%2961512-8\/fulltext\">an accompanying comment<\/a>,\u00a0Bo Netterstr\u00f8m writes that &#8220;job strain is a measure of only part of a psychosocially damaging work environment, which implies that prevention of workplace stress could reduce incidence of coronary heart disease to a greater extent than stated in the authors\u2019 interpretation of the calculated population-attributable risk for job strain.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study in the Lancet provides the best evidence yet that work-related stress and, in particular, job strain &#8212; &#8220;the combination of high job demands and low control at work&#8221; &#8212; plays a small but important role in causing heart disease. In order to address the limitations of previous studies on this topic, including [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[271,1454,1455],"class_list":["post-31822","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-risk-factors","tag-stress","tag-work"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=31822"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/31822\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=31822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=31822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=31822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}