{"id":33781,"date":"2012-12-21T16:12:40","date_gmt":"2012-12-21T21:12:40","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=33781"},"modified":"2012-12-21T16:13:27","modified_gmt":"2012-12-21T21:13:27","slug":"dabigatran-shouldnt-be-used-in-patients-with-mechanical-heart-valves","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2012\/12\/21\/dabigatran-shouldnt-be-used-in-patients-with-mechanical-heart-valves\/","title":{"rendered":"Dabigatran Shouldn&#8217;t Be Used in Patients with Mechanical Heart Valves"},"content":{"rendered":"<p>Dabigatran (Pradaxa) should not be prescribed to prevent blood clots or stroke in patients with mechanical heart valves, <a href=\"http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm332949.htm\">the FDA warned<\/a>.<\/p>\n<p>The warning follows the termination of a European clinical trial in which patients taking dabigatran had more frequent thromboembolic events than those on warfarin. Dabigatran patients also experienced more bleeding after valve surgery.<\/p>\n<p>Patients with mechanical heart valves should be transitioned from dabigatran to another anticoagulant, the FDA recommends; stopping dabigatran use suddenly can increase blood clot and stroke risk.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dabigatran (Pradaxa) should not be prescribed to prevent blood clots or stroke in patients with mechanical heart valves, the FDA warned. The warning follows the termination of a European clinical trial in which patients taking dabigatran had more frequent thromboembolic events than those on warfarin. Dabigatran patients also experienced more bleeding after valve surgery. Patients [&hellip;]<\/p>\n","protected":false},"author":622,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[495,1],"tags":[339,1590],"class_list":["post-33781","post","type-post","status-publish","format-standard","hentry","category-anticoagulation-2","category-general","tag-dabigatran","tag-mechanical-heart-valves"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/33781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/622"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=33781"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/33781\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=33781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=33781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=33781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}