{"id":33999,"date":"2013-01-08T16:13:37","date_gmt":"2013-01-08T21:13:37","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&p=33999"},"modified":"2013-01-08T16:45:04","modified_gmt":"2013-01-08T21:45:04","slug":"two-retractions-for-embattled-chief-investigator-of-kyoto-heart-study","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/01\/08\/two-retractions-for-embattled-chief-investigator-of-kyoto-heart-study\/","title":{"rendered":"Two Retractions for Embattled Chief Investigator of KYOTO HEART Study"},"content":{"rendered":"

\"\"<\/a><\/p>\n

The editor of\u00a0Circulation Journal<\/em>, the official journal of the Japanese Circulation Society (and not to be confused with the\u00a0American Heart Association’s [AHA’s] better known\u00a0Circulation<\/em>) has\u00a0announced<\/a>\u00a0the retraction of two substudies from\u00a0the KYOTO HEART Study<\/a>. The papers, according to the editor, “contain a number of serious errors in data analysis.” The announcement contained no additional information about the retractions.<\/p>\n

Last March<\/a>, following accusations by independent bloggers in\u00a0Japan\u00a0and\u00a0Germany, the AHA issued an\u00a0Expression of Concern<\/a>\u00a0about five papers published in AHA journals co-authored by Hiroaki Matsubara, who was a prominent cardiologist and researcher at Kyoto Prefectural University in\u00a0Japan, the author of many papers exploring the basic science of the renin-angiotensin system, and the chief investigator of the KYOTO HEART Study, a randomized, open-label trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.<\/p>\n

These are the two papers retracted by\u00a0Circulation Journal<\/em>:<\/p>\n

Shinzo Kimura, Takahisa Sawada, Jun Shiraishi, Hiroyuki Yamada, Hiroaki Matsubara; for the KYOTO HEART Study Group. Effects of valsartan on cardiovascular morbidity and mortality in high-risk hyper- tensive patients with new-onset diabetes mellitus: Sub-analysis of the KYOTO HEART Study. Circ J 2012 September 12 [Epub ahead of print].<\/p>\n

Jun Shiraishi, Takahisa Sawada, Shinzo Kimura, Hiroyuki Yamada, Hiroaki Matsubara; for the KYOTO HEART Study Group. Enhanced cardiovascular protective effects of valsartan in high-risk hypertensive patients with left ventricular hypertrophy: Sub-analysis of the KYOTO HEART study. Circ J 2011; 75: 806 \u2013 814.<\/p>\n

It may be worth noting that the first paper was published in September 2012, several months\u00a0after<\/em>\u00a0the AHA’s initial expression of concern about Matsubara’s publications.<\/p>\n

Sripal Bangalore, who was a co-author of\u00a0an editorial on the KYOTO HEART Study<\/a>\u00a0when it was initially published, said the new developments may raise questions about the main finding of the the study:<\/p>\n

\u201cThis may be just the tip of the iceberg. We need to know more details about whether it was a \u2018data analysis\u2019 error or fradulent data. Nevertheless, it does cast a serious doubt on the main results also \u2014 which if you remember was a significant benefit for Valsartan that was not explained by blood pressure and the curves started separating within 3 months. However, this is conjecture at this point.\u201d<\/p><\/blockquote>\n

 <\/p>\n

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 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The editor of\u00a0Circulation Journal, the official journal of the Japanese Circulation Society (and not to be confused with the\u00a0American Heart Association’s [AHA’s] better known\u00a0Circulation) has\u00a0announced\u00a0the retraction of two substudies from\u00a0the KYOTO HEART Study. The papers, according to the editor, “contain a number of serious errors in data analysis.” The announcement contained no additional information about […]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[1617,970,969,1478],"class_list":["post-33999","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-kyoto-heart-study","tag-retractions","tag-scientific-misconduct","tag-valsartan"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/33999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=33999"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/33999\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=33999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=33999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=33999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}