{"id":35304,"date":"2013-03-11T16:04:29","date_gmt":"2013-03-11T20:04:29","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&p=35304"},"modified":"2013-03-11T16:04:29","modified_gmt":"2013-03-11T20:04:29","slug":"selections-from-richard-lehmans-literature-review-march-11th","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/03\/11\/selections-from-richard-lehmans-literature-review-march-11th\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: March 11th"},"content":{"rendered":"

CardioExchange is pleased to reprint selections from Dr. Richard Lehman\u2019s\u00a0weekly journal review blog<\/a>\u00a0at\u00a0BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0entire blog<\/a>.<\/em><\/p>\n

JAMA\u00a0 6 Mar 2013\u00a0 Vol 309<\/strong><\/p>\n

Antiplatelet Therapy to Prevent CV Events and Mortality in Patients With Intermittent Claudication (pg. 926):\u00a0<\/strong> We\u2019ve become accustomed to giving low dose aspirin to people at higher cardiovascular risk, and clearly people with intermittent claudication count as that. Most of them have smoked and all of them have narrowed leg arteries. This clinical review<\/a> confirms that all anti-platelet therapies do indeed reduce adverse cardiovascular events in people with leg claudication. Clopidogrel may be more effective than aspirin. So should all patients with peripheral vascular disease be given a platelet inhibitor? Until the last few weeks, I\u2019d have said of course. But people who have smoked are at highest risk of macular degeneration, and we now know that aspirin doubles that risk. We don\u2019t know if clopidogrel does the same. So we really don\u2019t know how to advise our patients about the balance between the risk of a heart attack and the risk of blindness.<\/p>\n

It may take months or years before anyone gives us the answer, but it is literally at our fingertips. Anyone who has access to a good enough database such as the UK CPRD can feed in search terms such as aspirin, clopidogrel, claudication, PVD, myocardial infarction, and macular degeneration and get the figures. Put them through suitable statistical software and the observational data could be on line within hours. Anyone with the right skills, sitting in an office in Cardiff or Azerbaijan, could provide this information in real time to clinicians across the world. It is high time somebody set up this service.<\/p>\n

NEJM\u00a0 7 Mar 2013\u00a0 Vol 368<\/strong><\/p>\n

Endovascular Therapy After Intravenous t-PA vs. t-PA Alone for Stroke (pg. 893):<\/strong>\u00a0 Cut off from oxygenated blood, brain cells die very quickly. The wonder is not that thrombolysis makes so little difference in ischaemic stroke but that it makes any difference at all. The alternative to dissolving the clot is removing it using some type of endovascular procedure, but this takes even longer to organise because it requires a specialised unit with rapid access angiographic facilities. \u201cCurrent endovascular approaches include endovascular pharmacologic thrombolysis, manipulation of the clot with the use of a guidewire or microcatheter, mechanical and aspiration thrombectomy, and most recently, stent-retriever technology.\u201d Don\u2019t ask me what the last item means.<\/p>\n

This paper<\/a> reports the results of a large stroke trial in which initial treatment with intravenous t-PA was followed by endovascular treatment of any kind preferred by the operator, in the hope of getting early lysis followed a little while after by vessel clearance. It was stopped early because of futility after 656 participants had undergone randomisation. Removing the clot after the damage has been done is not a recipe for success.<\/p>\n

Endovascular Treatment for Acute Ischemic Stroke (pg. 904):<\/strong> So how do the two strategies compare if deployed as early as possible in a head-on randomised trial? The answer is that they are equally bad. This Italian trial<\/a> was much smaller than the previous one and again there was operator discretion when it came to the actual technique used for endovascular clot disruption\/removal.<\/p>\n

There are various signs of over-pragmatism in this trial<\/a>\u2014patients were treated within a maximum of 2.5 hours but randomised within 4.5 hours, and on the vexed question of consent during an evolving stroke, we are told that \u201ccompetent patients gave written informed consent before enrollment; otherwise, a witnessed waiver of consent was possible.\u201d Just so you know: if I have a big stroke, the intravenous treatment I would prefer is a soluble anaesthetic followed by a large slug of potassium chloride.<\/p>\n

Imaging Selection and Endovascular Treatment for Ischemic Stroke (pg. 914):<\/strong> But it might still be argued that there is a place for endovascular stroke treatment if only we know how to select the right patients. Pleading from subgroups and \u201cjudicious selection\u201d is always the last refuge of a failing intervention, and so it proves here. The patients who should benefit from mechanical clot removal are those with a \u201cfavourable penumbral pattern\u201d on imaging\u2014meaning a small core infarct surrounded by a lot of salvageable brain tissue.<\/p>\n

So this trial<\/a> was set up to compare endovascular treatment with usual care within a generous time frame (8 hours) and to stratify patients according to a favourable or unfavourable penumbral pattern. It ended up demonstrating that \u201cneuroimaging did not identify patients who would differentially benefit from endovascular therapy for acute ischemic stroke, nor was embolectomy shown to be superior to standard care.\u201d<\/p>\n

Judging from these three trials, embolectomy seems yet another blind alley in the treatment of acute ischaemic stroke. Use t-PA in suitable patients caught within an hour or so: otherwise let nature take its often brutal course, because there is nothing you can do about it.<\/p>\n

Lancet\u00a0 9 Mar 2013\u00a0 Vol 381<\/strong><\/p>\n

Safety and Performance of the Drug-Eluting Absorbable Metal Scaffold (DREAMS) in Patients with De-Novo Coronary Lesions (pg. 836):<\/strong> From the sublime to the ridiculous. Here\u2019s the interpretation of this study<\/a>: \u201cOur results show feasibility, a good safety profile, and promising clinical and angiographic performance results up to 12 months for DREAMS. Our promising clinical results show that absorbable metal scaffolds might be an alternative to polymeric absorbable scaffolds.\u201d What? Since when did \u201cpromising\u201d and \u201cmight\u201d amount to a clinically significant result? Has this even been edited for its English (\u201cpromising\u201d in two successive sentences)? And who does the \u201cour\u201d refer to? Step up Biotronik, who made and named the DREAMS stent, paid for the study, and \u201chad roles in study design; monitoring; and data collection, analysis, and interpretation.\u201d Would they by any chance be interested in buying up a few reprints from Elsevier?<\/p>\n","protected":false},"excerpt":{"rendered":"

This week’s topics include antiplatelet therapy to prevent CV events and mortality in those with intermittent claudication, endovascular treatment for stroke, and more.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[463,1724,1723,1722,1721,253],"class_list":["post-35304","post","type-post","status-publish","format-standard","hentry","category-general","tag-antiplatelet-therapy","tag-coronary-lesions","tag-drug-eluting-absorbable-metal-scaffold","tag-endovascular-therapy","tag-intemittent-claudication","tag-stroke"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=35304"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35304\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=35304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=35304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=35304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}