{"id":35427,"date":"2013-03-12T15:41:11","date_gmt":"2013-03-12T19:41:11","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=35427"},"modified":"2013-03-12T15:47:43","modified_gmt":"2013-03-12T19:47:43","slug":"sildenafil-does-not-improve-exercise-capacity-in-hf-with-preserved-ejection-fraction","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/03\/12\/sildenafil-does-not-improve-exercise-capacity-in-hf-with-preserved-ejection-fraction\/","title":{"rendered":"Sildenafil Does Not Improve Exercise Capacity in HF with Preserved Ejection Fraction"},"content":{"rendered":"<p>Sildenafil does not improve exercise capacity or clinical status in patients with symptomatic heart failure (HF) and preserved ejection fraction, according to <a href=\"http:\/\/jama.jamanetwork.com\/article.aspx?articleid=1663257\">a <em>JAMA<\/em> study<\/a>. This finding contrasts with previous research suggesting a potential benefit in such patients.<\/p>\n<p>Some 220 HF patients with ejection fractions of 50% or greater were randomized to receive oral sildenafil or placebo for 24 weeks. Most were already taking diuretics, renin-angiotensin system antagonists, beta-blockers, and statins.<\/p>\n<p>At the end of treatment, there were no significant differences between the groups in peak oxygen consumption, 6-minute walk distance, or a clinical status score based, in part, on time to death or hospitalization.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sildenafil does not improve exercise capacity or clinical status in patients with symptomatic heart failure (HF) and preserved ejection fraction, according to a JAMA study. This finding contrasts with previous research suggesting a potential benefit in such patients. Some 220 HF patients with ejection fractions of 50% or greater were randomized to receive oral sildenafil [&hellip;]<\/p>\n","protected":false},"author":577,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[749,287,1703,1727],"class_list":["post-35427","post","type-post","status-publish","format-standard","hentry","category-heart-failure","tag-exercise","tag-heart-failure-2","tag-preserved-ejection-fraction","tag-sildenafil"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/577"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=35427"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35427\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=35427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=35427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=35427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}