{"id":35524,"date":"2013-03-18T15:17:46","date_gmt":"2013-03-18T19:17:46","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&p=35524"},"modified":"2013-03-19T10:55:41","modified_gmt":"2013-03-19T14:55:41","slug":"selections-from-richard-lehmans-literature-review-march-18th","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/03\/18\/selections-from-richard-lehmans-literature-review-march-18th\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: March 18th"},"content":{"rendered":"

CardioExchange is pleased to reprint selections from Dr. Richard Lehman\u2019s\u00a0weekly journal review blog<\/a>\u00a0at\u00a0BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0entire blog<\/a>.<\/em><\/p>\n

JAMA\u00a0 13 Mar 2013\u00a0 Vol 309<\/strong><\/p>\n

Association of Smoking Cessation and Weight Change With CV Disease Among Adults With and Without Diabetes (pg. 1014):<\/strong> It\u2019s a troublesome fact that most people who give up smoking (and come off nicotine replacement) gain weight. Together with the desperately addictive qualities of nicotine, this is a major cause for people to continue smoking. I am sure that you already tell them that the health benefits of giving up far outweigh the health hazards of a few extra pounds in weight; and the Framingham Offspring Study<\/a> proves you right, with 6 years of follow-up showing a halving of cardiovascular events in the quitters, irrespective of weight gain.<\/p>\n

NEJM\u00a0 14 Mar 2013\u00a0 Vol 368<\/strong><\/p>\n

Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer (pg. 987):<\/strong> Last week, I lambasted the NEJM<\/em> for publishing a truly terrible pharma-funded trial, but this week there are none of these, presumably because the feeding needs of the publishers have been satisfied for the time being. I await next week\u2019s issue with interest. Meanwhile, enjoy this excellent study based on long-term data<\/a> from all women in Stockholm and Denmark who underwent radiotherapy for breast cancer under the age of 70 between 1958 and 2001 in the case of the Swedes, and under the age of 75 between 1977 and 2000 in the case of the Danes. Their radiation doses were calculated using original records where possible, and they were compared with carefully matched controls for the occurrence of cardiac events. These themselves were carefully validated from hospital records and autopsies. \u201cExposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease. The increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years. Women with preexisting cardiac risk factors have greater absolute increases in risk from radiotherapy than other women.\u201d Observational science at its best.<\/p>\n

Long-Term Outcomes in Elderly Survivors of In-Hospital Cardiac Arrest (pg. 1019):<\/strong> If you\u2019re looking for great outcomes research in cardiology, you could find most of it by going to PubMed and searching under the names of Harlan Krumholz, John Spertus, and increasingly Brahmajee Nallamothu. Not too surprising, then, that all three of these names appear on this paper<\/a> about long-term outcomes in elderly survivors of in-hospital cardiac arrest. The figures are much better than you might surmise: \u201cAmong elderly survivors of in-hospital cardiac arrest, nearly 60% were alive at 1 year, and the rate of 3-year survival was similar to that among patients with heart failure. Survival and readmission rates differed according to the demographic characteristics of the patients and neurologic status at discharge.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

This week’s topics include the association between smoking cessation and weight change with CV disease among those with and without diabetes, the risk of ischemic heart disease in women after radiotherapy for breast cancer, and more.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[645,818,1731,1733,1568,1732,1726,1272,1405,698],"class_list":["post-35524","post","type-post","status-publish","format-standard","hentry","category-general","tag-breast-cancer","tag-elderly","tag-framingham-offspring-study","tag-in-hosital-cardiac-arrest","tag-ischemic-heart-disease","tag-long-term-outcomes","tag-radiotherapy","tag-smoking-cessation","tag-weight","tag-women"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=35524"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35524\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=35524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=35524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=35524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}