{"id":35562,"date":"2013-03-20T13:38:37","date_gmt":"2013-03-20T17:38:37","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=35562"},"modified":"2013-03-20T13:38:37","modified_gmt":"2013-03-20T17:38:37","slug":"chlorthalidone-associated-with-more-electrolyte-problems-than-hydrochlorothiazide","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/03\/20\/chlorthalidone-associated-with-more-electrolyte-problems-than-hydrochlorothiazide\/","title":{"rendered":"Chlorthalidone Associated with More Electrolyte Problems Than Hydrochlorothiazide"},"content":{"rendered":"<p>The diuretics chlorthalidone and hydrochlorothiazide are similarly effective at preventing cardiovascular events among older adults with hypertension, but electrolyte abnormalities are more common with chlorthalidone, according to <a href=\"http:\/\/annals.org\/article.aspx?articleid=1667266\">a study in the <em>Annals of Internal Medicine<\/em><\/a>.<\/p>\n<p>Canadian researchers used healthcare databases to identify nearly 30,000 adults over age 65 recently prescribed varying doses of chlorthalidone or hydrochlorothiazide. During follow-up, the rate of the primary outcome &#8212; a composite of death or hospitalization for MI, stroke, or heart failure &#8212; did not differ significantly between the chlorthalidone and hydrochlorothiazide groups (3.2 and 3.4 events per 100 person-years).<\/p>\n<p>Hospitalization for hypokalemia was more likely among chlorthalidone recipients (0.69 vs. 0.27 events per 100 person-years), as was hospitalization for hyponatremia.<\/p>\n<p>The authors conclude that in the absence of a large, randomized trial comparing the two treatments, &#8220;it may be reasonable to conclude that hydrochlorothiazide is safer than chlorthalidone in elderly patients at typically prescribed doses.&#8221;<\/p>\n<p><em>Reprinted with permission from<\/em> <a href=\"http:\/\/firstwatch.jwatch.org\/\">Physician&#8217;s First Watch<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The diuretics chlorthalidone and hydrochlorothiazide are similarly effective at preventing cardiovascular events among older adults with hypertension, but electrolyte abnormalities are more common with chlorthalidone, according to a study in the Annals of Internal Medicine. Canadian researchers used healthcare databases to identify nearly 30,000 adults over age 65 recently prescribed varying doses of chlorthalidone or [&hellip;]<\/p>\n","protected":false},"author":494,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1658,7],"tags":[1738,454],"class_list":["post-35562","post","type-post","status-publish","format-standard","hentry","category-hypertension-3","category-prevention","tag-diuretic","tag-hypertension"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/494"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=35562"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/35562\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=35562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=35562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=35562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}