{"id":36869,"date":"2013-05-28T18:07:04","date_gmt":"2013-05-28T22:07:04","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=36869"},"modified":"2013-05-28T18:07:04","modified_gmt":"2013-05-28T22:07:04","slug":"interpretations-differ-over-study-of-coenzyme-q10-in-heart-failure","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/05\/28\/interpretations-differ-over-study-of-coenzyme-q10-in-heart-failure\/","title":{"rendered":"Interpretations Differ Over Study of Coenzyme Q10 in Heart Failure"},"content":{"rendered":"<p>Coenzyme Q10 (CoQ10) may be beneficial in heart failure (HF), according to the results of\u00a0<a href=\"http:\/\/spo.escardio.org\/SessionDetails.aspx?eevtid=61&amp;fp=440&amp;doc=abstract#.UaS78pWc6bt\">the Q-SYMBIO study presented this past weekend at the\u00a0Heart Failure 2013 meeting in Lisbon, Portugal<\/a>. But the results should be viewed with a critical eye, say experts.<\/p>\n<p>A possible role for CoQ10 in the treatment of HF has long been proposed.\u00a0<a href=\"http:\/\/ajcn.nutrition.org\/content\/97\/2\/268.abstract\">A recent meta-analysis<\/a>\u00a0found that CoQ10 may improve ejection fraction (EF) in HF patients, but the authors\u00a0warned that &#8220;the results should be interpreted with caution&#8221; due to the small number of studies and patients included in the analysis.<\/p>\n<p>Q-SYMBIO is now the largest trial to date of CoQ10 in HF in the modern era. SA Mortensen\u00a0presented results from 420 patients with class III or IV HF who were randomized to CoQ10 three times daily or placebo. After two years there was a significant reduction in the incidence of major adverse cardiovascular events in the CoQ10 group: 14% (29 patients) in the CoQ10 group versus 25% (55 patients) in the placebo group (hazard ratio 2.0, CI 1.3-3.2, p=0.003). Mortensen also reported a significant reduction in overall mortality: 9% (18 patients) in the CoQ10 group versus 17% (36 patients) in the placebo group (HR 2.1, CI 1.2-3.8, p=0.01). There were also significant reductions in cardiovascular mortality\u00a0(p=0.02) and HF hospitalizations (p=0.05).<\/p>\n<p>In\u00a0<a href=\"http:\/\/www.escardio.org\/about\/press\/press-releases\/pr-13\/Pages\/first-drug-in-decade-improves-heart-failure-mortality.aspx\">an ESC press release,<\/a> Mortensen said: \u201cCoQ10 is the first medication to improve survival in chronic heart failure since\u00a0ACE\u00a0inhibitors and beta blockers more than a decade ago and should be added to standard heart failure therapy.\u201d CoQ10, he said, &#8220;is a natural and safe substance, corrects a deficiency in the body and blocks the vicious metabolic cycle in chronic heart failure called the energy starved heart.\u201d<\/p>\n<p>But the results\u00a0of Q-SYMBIO are &#8220;not practice changing&#8221; Aldo Maggioni told\u00a0<a href=\"http:\/\/www.medpagetoday.com\/MeetingCoverage\/HFC\/39424?utm_source=cardio-meetings&amp;utm_medium=email&amp;utm_content=acc&amp;utm_campaign=05%7C28%7C2013&amp;userid=19517&amp;eun=g61458d2r&amp;email=lhusten@mit.edu&amp;mu_id=5019050\">MedPage Today<\/a>. He pointed to the small number of patients and events in the trial.\u00a0&#8220;You cannot change clinical practice all over Europe basing your conclusion on that.&#8221;<\/p>\n<p>&nbsp;<\/p>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Coenzyme Q10 (CoQ10) may be beneficial in heart failure (HF), according to the results of\u00a0the Q-SYMBIO study presented this past weekend at the\u00a0Heart Failure 2013 meeting in Lisbon, Portugal. But the results should be viewed with a critical eye, say experts. A possible role for CoQ10 in the treatment of HF has long been proposed.\u00a0A [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[1833],"class_list":["post-36869","post","type-post","status-publish","format-standard","hentry","category-heart-failure","tag-coenzyme-q10"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/36869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=36869"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/36869\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=36869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=36869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=36869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}