{"id":3834,"date":"2010-10-08T12:17:37","date_gmt":"2010-10-08T16:17:37","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=3834"},"modified":"2011-07-19T17:44:46","modified_gmt":"2011-07-19T21:44:46","slug":"analysis-of-advance-explores-role-of-hypoglycemia","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/10\/08\/analysis-of-advance-explores-role-of-hypoglycemia\/","title":{"rendered":"Analysis of ADVANCE Explores Role of Hypoglycemia"},"content":{"rendered":"<p>A new analysis of the <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa0802987\">ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation)\u00a0trial<\/a> sheds light on the role of hypoglycemia in recent trials of glucose control. In a<a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1003795#t=abstract\"> paper in the <\/a><em><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1003795#t=abstract\">New England Journal of Medicine<\/a><\/em>, the ADVANCE investigators report that 2.1% of 11,140 patients with type 2 diabetes developed severe hypoglycemia in the course of the trial. Patients with severe hypoglycemia had a significantly elevated risk of major macrovascular events, major microvascular events, and death from a cardiovascular cause or from any cause.<\/p>\n<p>However, the investigators did not find either a temporal or a dose-response relationship between hypoglycemia and outcome. The authors conclude that &#8220;although our findings cannot exclude the possibility that severe hypoglycemia has a direct causal link with these outcomes, they suggest that it is as likely to be a marker of vulnerability to a wide range of adverse clinical outcomes.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation)\u00a0trial sheds light on the role of hypoglycemia in recent trials of glucose control. In a paper in the New England Journal of Medicine, the ADVANCE investigators report that 2.1% of 11,140 patients with type 2 diabetes [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7,16],"tags":[200,468,471,470,469],"class_list":["post-3834","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","category-vascular","tag-diabetes","tag-glucose-control","tag-hypoglycemia","tag-intensive-glucose-control","tag-type-2-diabetes"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/3834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=3834"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/3834\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=3834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=3834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=3834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}