{"id":39740,"date":"2013-11-06T22:21:37","date_gmt":"2013-11-07T03:21:37","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=39740"},"modified":"2013-11-06T22:21:37","modified_gmt":"2013-11-07T03:21:37","slug":"ace-inhibitors-angiotensin-receptor-blockers-tied-to-increase-in-kidney-admissions","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2013\/11\/06\/ace-inhibitors-angiotensin-receptor-blockers-tied-to-increase-in-kidney-admissions\/","title":{"rendered":"ACE Inhibitors, Angiotensin-Receptor Blockers Tied to Increase in Kidney Admissions"},"content":{"rendered":"<p>Increases in prescriptions for angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in recent years may have contributed to an increase in hospital admissions for acute kidney injury, according to a <a href=\"http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0078465\"><em>PLoS ONE<\/em> study<\/a>.<\/p>\n<p>U.K. researchers examined national prescription and hospital admission data from April 2007 through March 2011. Nationwide, ACE-inhibitor and ARB prescriptions increased by about 16% &#8212; and admissions for acute kidney injury by 52% &#8212; over the study period. In addition, there was &#8220;strong evidence&#8221; that increases in ACE-inhibitor and ARB prescriptions within particular general practices corresponded to increases in kidney hospitalizations within those practices. The researchers calculate that increases in such prescriptions accounted for 15% (roughly 11,000) of the overall rise in kidney admissions.<\/p>\n<p>CardioExchange&#8217;s Harlan Krumholz commented: &#8220;This ecological analysis should be interpreted cautiously, as the researchers were limited in their ability to link the use of ACE inhibitors and ARBs by individual patients with an increase in risk. This does not mandate a change in practice. What I find most concerning is the increase in acute kidney injury &#8212; and there is an urgent need for patient-level studies to determine what is fueling the elevation in risk.&#8221;<\/p>\n<p><em>Originally published in<\/em> <a href=\"http:\/\/www.jwatch.org\/medical-news\">Physician&#8217;s First Watch<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Increases in prescriptions for angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in recent years may have contributed to an increase in hospital admissions for acute kidney injury, according to a PLoS ONE study. U.K. researchers examined national prescription and hospital admission data from April 2007 through March 2011. Nationwide, ACE-inhibitor and ARB prescriptions [&hellip;]<\/p>\n","protected":false},"author":577,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-39740","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/39740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/577"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=39740"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/39740\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=39740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=39740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=39740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}