{"id":41047,"date":"2014-01-13T10:54:58","date_gmt":"2014-01-13T15:54:58","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&p=41047"},"modified":"2014-01-13T10:54:58","modified_gmt":"2014-01-13T15:54:58","slug":"selections-from-richard-lehmans-literature-review-january-13th","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2014\/01\/13\/selections-from-richard-lehmans-literature-review-january-13th\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: January 13th"},"content":{"rendered":"

CardioExchange is pleased to reprint this selection from Dr. Richard Lehman\u2019s\u00a0weekly journal review blog<\/a>\u00a0at\u00a0BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0entire blog<\/a>.<\/em><\/p>\n

JAMA Internal Medicine\u00a0 Jan 2014\u00a0 Vol 174<\/strong><\/p>\n

MI and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome (pg. 15):<\/strong> I can remember chatting with a cardiology professor about fifteen years ago, when the concepts of \u201cinsulin resistance\u201d and the \u201cmetabolic syndrome\u201d were becoming fashionable. \u201cIt\u2019s just a way of calling people fat, isn\u2019t it?\u201d he said. And that, by and large, is what this Danish population study<\/a> finds. \u201cWe examined 71\u2009527 individuals from the Copenhagen General Population Study and categorized them according to body mass index (BMI) as normal weight, overweight, or obese and according to absence or presence of metabolic syndrome.\u201d \u201cConclusions and Relevance:\u00a0 These findings suggest that overweight and obesity are risk factors for MI and IHD regardless of the presence or absence of metabolic syndrome and that metabolic syndrome is no more valuable than BMI in identifying individuals at risk.\u201d<\/p>\n

Lower Risk of CV Events in Postmenopausal Women Taking Oral Estradiol Compared With Oral Conjugated Equine Estrogens (pg. 25):<\/strong> Ever since the Women\u2019s Health Initiative trial showed increased risk in women randomised to postmenopausal hormone replacement, doctors have been beating themselves up for prescribing oestrogens so widely for menopausal symptoms. But actually we were often prescribing different drugs from those used in WHI to women quite different from the WHI subjects. In the trial, the oestrogen used was the old fashioned one derived from pregnant mares\u2019 urine\u2014Premarin or conjugated equine estrogens (CEEs). Moving to American spellings, the alternative is synthetic estradiol. And here is another North American study<\/a> showing that the two have different risks: \u201cIn an observational study of oral hormone therapy users, CEEs use was associated with a higher risk of incident venous thrombosis and possibly myocardial infarction than estradiol use.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

This week’s topics include the risk for MI and ischemic heart disease among overweight and obese people with and without metabolic syndrome, and the lower risk for CV events in postmenopausal women taking estradiol compared with conjugated equine estrogens.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[329,2002,1568,730,1314,284,2132,1503],"class_list":["post-41047","post","type-post","status-publish","format-standard","hentry","category-general","tag-cardiovascular-risk","tag-estrogen","tag-ischemic-heart-disease","tag-metabolic-syndrome","tag-myocardial-infarction","tag-obesity","tag-overweight","tag-womens-health-initiative"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/41047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=41047"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/41047\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=41047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=41047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=41047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}