{"id":4233,"date":"2010-11-01T05:34:43","date_gmt":"2010-11-01T09:34:43","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=4233"},"modified":"2011-07-19T17:44:44","modified_gmt":"2011-07-19T21:44:44","slug":"rivaroxaban-equals-warfarin-in-rocket-af","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/11\/01\/rivaroxaban-equals-warfarin-in-rocket-af\/","title":{"rendered":"Rivaroxaban Equals Warfarin in ROCKET AF"},"content":{"rendered":"<p>Rivaroxaban (Xarelto) was as effective as warfarin in patients with AF in t<a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00403767?term=rivaroxaban&amp;rank=7\">he ROCKET AF study<\/a>, <a href=\"http:\/\/www.investor.bayer.com\/user_upload\/3668\/\">according to an announcement released by Bayer on Sunday<\/a> ahead of the\u00a0 trial&#8217;s scheduled presentation at the AHA on November 15.<\/p>\n<p>ROCKET AF randomized more than 14,000 patients with nonvalvular AF to either rivaroxaban or warfarin. The goal of the study was to establish the noninferiority of rivaroxaban to warfarin. The primary efficacy endpoint  was a composite of all-cause stroke and non-CNS systemic embolism. The primary safety endpoint was the composite of major and non-major clinically relevant bleeding events.<\/p>\n<p>The Bayer announcement states: &#8220;Rivaroxaban has met its primary efficacy endpoint versus dose-adjusted warfarin. The rates of the composite of major and non-major clinically relevant bleeding were comparable.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rivaroxaban (Xarelto) was as effective as warfarin in patients with AF in the ROCKET AF study, according to an announcement released by Bayer on Sunday ahead of the\u00a0 trial&#8217;s scheduled presentation at the AHA on November 15. ROCKET AF randomized more than 14,000 patients with nonvalvular AF to either rivaroxaban or warfarin. The goal of [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[495,13,7],"tags":[365,492,366,342,489,368],"class_list":["post-4233","post","type-post","status-publish","format-standard","hentry","category-anticoagulation-2","category-electrophysiology","category-prevention","tag-af","tag-anticoagulation","tag-rivaroxaban","tag-spaf","tag-stroke-prevention","tag-warfarin"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4233","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=4233"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4233\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=4233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=4233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=4233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}