{"id":42702,"date":"2014-04-08T19:38:47","date_gmt":"2014-04-08T23:38:47","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=42702"},"modified":"2014-04-08T19:45:20","modified_gmt":"2014-04-08T23:45:20","slug":"nsaid-use-associated-with-atrial-fibrillation-in-older-people","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2014\/04\/08\/nsaid-use-associated-with-atrial-fibrillation-in-older-people\/","title":{"rendered":"NSAID Use Associated with Atrial Fibrillation in Older People"},"content":{"rendered":"<p>Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the elderly is associated with an increased risk for atrial fibrillation (AF), according to a prospective study in <em>BMJ Open<\/em>.<\/p>\n<p>Using a Dutch cohort designed to investigate risk factors of disease onset in the aged, <a href=\"http:\/\/bmjopen.bmj.com\/content\/4\/4\/e004059\">researchers followed some 8400 people for 13 years.<\/a> None had AF at baseline (when their mean age was 69 years).<\/p>\n<p>Current use of NSAIDs for 15 to 30 days was associated with a higher AF risk, relative to never use (adjusted hazard ratio, 1.76). Use in the recent past (within the past 30 days) also brought increased risk (HR, 1.84). There was a suggestive dose-response relation, but it didn&#8217;t reach statistical significance.<\/p>\n<p>The authors speculate that, in addition to possible effects on blood pressure, NSAIDs could cause fluctuations in serum potassium, possibly contributing to the observed association.<\/p>\n<p><em>Adapted from <a href=\"http:\/\/www.jwatch.org\/medical-news\">Physician&#8217;s First Watch<\/a><\/em><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the elderly is associated with an increased risk for atrial fibrillation (AF), according to a prospective study in BMJ Open. Using a Dutch cohort designed to investigate risk factors of disease onset in the aged, researchers followed some 8400 people for 13 years. None had AF at baseline [&hellip;]<\/p>\n","protected":false},"author":494,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[341,650],"class_list":["post-42702","post","type-post","status-publish","format-standard","hentry","category-heart-failure","tag-atrial-fibrillation","tag-nsaids"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/42702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/494"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=42702"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/42702\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=42702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=42702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=42702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}