{"id":4311,"date":"2010-11-02T11:56:20","date_gmt":"2010-11-02T15:56:20","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=4311"},"modified":"2011-07-19T17:44:44","modified_gmt":"2011-07-19T21:44:44","slug":"meta-analysis-provides-little-support-for-prophylactic-icd-use-in-older-adults","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/11\/02\/meta-analysis-provides-little-support-for-prophylactic-icd-use-in-older-adults\/","title":{"rendered":"Meta-Analysis Provides Little Support for Prophylactic ICD Use in Older Adults"},"content":{"rendered":"<p>Prophylactic implantable cardioverter-defibrillator (ICD) therapy does not appear to significantly improve survival among older adults with severe left ventricular dysfunction, according to a <a href=\"http:\/\/www.annals.org\/content\/153\/9\/592.abstract\">meta-analysis in the <\/a><em><a href=\"http:\/\/www.annals.org\/content\/153\/9\/592.abstract\">Annals of Internal Medicine<\/a>.<\/em><\/p>\n<p>Researchers analyzed data from five randomized trials comparing ICD therapy with medical treatment among some 5800 adults with cardiomyopathy. Older adults (defined as 60 and older in some trials and 65 and older in others) accounted for nearly half the patients.<\/p>\n<p>The researchers found that while ICD therapy lowered mortality in younger patients, it did not have a significant impact on mortality in elders. Overall, 17% of patients experienced complications from their ICDs.<\/p>\n<p>The authors point to previous research showing that cardiac resynchronization therapy (CRT) seems to benefit the young and old alike, adding: &#8220;Taken together, these findings support that CRT alone may be the best device therapy in elderly persons with severe left ventricular dysfunction.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prophylactic implantable cardioverter-defibrillator (ICD) therapy does not appear to significantly improve survival among older adults with severe left ventricular dysfunction, according to a meta-analysis in the Annals of Internal Medicine. Researchers analyzed data from five randomized trials comparing ICD therapy with medical treatment among some 5800 adults with cardiomyopathy. Older adults (defined as 60 and [&hellip;]<\/p>\n","protected":false},"author":577,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,1,14],"tags":[287,448],"class_list":["post-4311","post","type-post","status-publish","format-standard","hentry","category-electrophysiology","category-general","category-heart-failure","tag-heart-failure-2","tag-icds"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/577"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=4311"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4311\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=4311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=4311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=4311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}