{"id":4403,"date":"2010-11-05T08:57:19","date_gmt":"2010-11-05T12:57:19","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=4403"},"modified":"2011-07-19T17:44:44","modified_gmt":"2011-07-19T21:44:44","slug":"meta-analysis-turns-up-mixed-results-for-vitamin-e-on-stroke-subtypes","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2010\/11\/05\/meta-analysis-turns-up-mixed-results-for-vitamin-e-on-stroke-subtypes\/","title":{"rendered":"Meta-Analysis Turns Up Mixed Results for Vitamin E on Stroke Subtypes"},"content":{"rendered":"<p>In <a href=\"http:\/\/www.bmj.com\/cgi\/doi\/10.1136\/bmj.c5702\">a meta-analysis appearing in <\/a><em><a href=\"http:\/\/www.bmj.com\/cgi\/doi\/10.1136\/bmj.c5702\">BMJ<\/a><\/em>, vitamin E supplements had no effect on the overall rate of stroke but were associated with a small reduction in the risk of ischemic stroke and a slightly larger increase in the risk of hemorrhagic stroke. Markus Sch\u00fcrks and colleagues analyzed data from 9 trials including 118,765 subjects. Although the investigators found no overall effect of vitamin E on the risk for total stroke, the risk of hemorrhagic stroke was raised by 22% while the risk for ischemic stroke was cut by 10%. They cautioned that the absolute<em> <\/em>effect was small, resulting in 0.8 more hemorrhagic strokes and 2.1 fewer ischemic strokes per 1000 people treated.<\/p>\n<p>Summarizing the clinical implications, they wrote: &#8220;Because the consequences of hemorrhagic stroke in terms of morbidity and mortality are generally more severe than those of ischemic stroke and high doses of vitamin E supplements may increase all cause mortality, a widespread and medically uncontrolled use of vitamin E should be cautioned.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a meta-analysis appearing in BMJ, vitamin E supplements had no effect on the overall rate of stroke but were associated with a small reduction in the risk of ischemic stroke and a slightly larger increase in the risk of hemorrhagic stroke. Markus Sch\u00fcrks and colleagues analyzed data from 9 trials including 118,765 subjects. Although [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[253,489,528],"class_list":["post-4403","post","type-post","status-publish","format-standard","hentry","category-prevention","tag-stroke","tag-stroke-prevention","tag-vitamin-e"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=4403"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/4403\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=4403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=4403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=4403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}