{"id":45420,"date":"2014-09-29T16:59:38","date_gmt":"2014-09-29T20:59:38","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&p=45420"},"modified":"2014-09-29T16:59:38","modified_gmt":"2014-09-29T20:59:38","slug":"selections-from-richard-lehmans-literature-review-september-29th","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2014\/09\/29\/selections-from-richard-lehmans-literature-review-september-29th\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: September 29th"},"content":{"rendered":"
\n

CardioExchange is pleased to reprint this selection from Dr. Richard Lehman\u2019s\u00a0weekly journal review blog<\/a>\u00a0at\u00a0BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0entire blog<\/a>.<\/em><\/p>\n

JAMA<\/em> 24 September 2014 Vol 312<\/strong><\/p>\n

Prevalence and Incidence Trends for Diagnosed Diabetes Among Adults Aged 20 to 79 Years, United States, 1980-2012 (pg. 1218):<\/strong> A survey of new diagnosis of diabetes in the USA<\/a> shows a doubling between 1990 and 2008, followed by a plateau, and even, wonder of wonders, a dip thereafter. This is virtually the same plot as obesity over there. And what about over here? I can\u2019t find an up to date plot, although Diabetes UK declares that \u201cMost health experts agree that the UK is facing a huge increase in the number of people with diabetes.\u201d I guess if I looked at the Tesco website a while ago I might have found that \u201cmost experts agree that Tesco is facing a huge increase in profits,\u201d but I would have done better to look at the account books.<\/p>\n

Lancet<\/em> 27 September 2014 Vol 384<\/strong><\/p>\n

Losmapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor, in Non-ST-Segment Elevation Myocardial Infarction (pg. 1187):<\/strong> I\u2019ve already warned you that we would be coming upon losmapimod. It is a p38 mitogen activated protein kinase inhibitor. Understand? It doesn\u2019t matter whether you do or not, because losmapimod did nothing at all in this phase 2 trial,\u00a0<\/a>where it was given for 12 weeks after\u00a0non-ST elevation myocardial infarction. At this rate, it won\u2019t even be around long enough to form a useful rhyme word with god.<\/p>\n

Ann Intern Med<\/em> 16 September 2014 Vol 161<\/strong><\/p>\n

Quality-of-Life Outcomes With Coronary Artery Bypass Graft Surgery in Ischemic Left Ventricular Dysfunction (pg. 392):<\/strong> I have been a bit neglectful towards the Annals of Internal Medicine<\/em> of late, but a sparse week in the other journals led me to look at it. It\u2019s perhaps worth pointing your attention to a randomised trial, which shows that coronary artery bypass surgery can be beneficial for some high risk patients<\/a> with ischemic left ventricular dysfunction. That was certainly my experience with two youngish patients who were constantly decompensating before they had surgery, but general practice can provide a very misleading sample, and most of my reading since then has suggested that \u201chibernating myocardium\u201d generally stays asleep, revascularise it as you may. But this trial, on patients with ejection fraction less than 35%,\u00a0randomly assigned 602 patients to medical therapy alone and 610 to medical therapy plus CABG. The main sustained improvement in the CABG group was in quality of life\u2014very worthwhile, since it can be pretty awful in this patient group.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

This week’s topics include prevalence and incidence trends in diabetes in the U.S., quality of life outcomes with CABG in ischemic left ventricular dysfunction, and more.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[231,200,2381,2382],"class_list":["post-45420","post","type-post","status-publish","format-standard","hentry","category-general","tag-cabg","tag-diabetes","tag-ischemic-left-ventricular-dysfunction","tag-losmapimod"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/45420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=45420"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/45420\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=45420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=45420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=45420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}