{"id":45648,"date":"2014-10-20T15:46:58","date_gmt":"2014-10-20T19:46:58","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&#038;p=45648"},"modified":"2014-10-20T15:46:58","modified_gmt":"2014-10-20T19:46:58","slug":"selections-from-richard-lehmans-literature-review-october-20th","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2014\/10\/20\/selections-from-richard-lehmans-literature-review-october-20th\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: October 20th"},"content":{"rendered":"<p><em>CardioExchange is pleased to reprint this selection from Dr. Richard Lehman\u2019s\u00a0<a href=\"http:\/\/blogs.bmj.com\/bmj\/category\/richard-lehmans-weekly-review-of-medical-journals\/\" target=\"_blank\">weekly journal review blog<\/a>\u00a0at\u00a0<a href=\"http:\/\/www.bmj.com\/\">BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0<a title=\"Lehman_8282012\" href=\"http:\/\/blogs.bmj.com\/bmj\/2014\/10\/20\/richard-lehmans-journal-review-20-october-2014\/\" target=\"_blank\">entire blog<\/a>.<\/em><\/p>\n<p><strong><em>Lancet<\/em> 18 October 2014 Vol 384<\/strong><\/p>\n<p><strong>The Safety of Addition of Nitrous Oxide to General Anesthesia in At-Risk Patients Having Major Non-Cardiac Surgery (pg. 1446):<\/strong>\u00a0 If you are about to undergo surgery and your anaesthetist wishes to use nitrous oxide, let not your heart be troubled. In <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2814%2960893-X\/abstract\">a randomised, assessor-blinded trial<\/a> in patients aged at least 45 years with known or suspected coronary artery disease having major non-cardiac surgery, nitrous oxide did not increase the risk of death or cardiovascular complications. In fact, you might want to try some at sub-anaesthetic doses just for pleasure. The first person to do this was the intrepid young Cornishman Humphry Davy in 1799, when he worked with Dr Beddoes at the Pneumatic Institute in Bath. You may experience \u201csublime emotion connected with highly vivid ideas,\u201d according to Davy\u2019s electrifying account of his extensive experiments on himself and others, <a href=\"http:\/\/publicdomainreview.org\/collections\/the-nitrous-oxide-experiments-of-humphry-davy\/\">which you can read page by page<\/a>.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This week&#8217;s topic is the safety of adding nitrous oxide to general anesthesia in patients with known or suspected coronary artery disease who are having major non-cardiac surgery.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[460,2398,2397],"class_list":["post-45648","post","type-post","status-publish","format-standard","hentry","category-general","tag-coronary-artery-disease","tag-general-anesthesia","tag-nitrous-oxide"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/45648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=45648"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/45648\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=45648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=45648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=45648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}