{"id":47205,"date":"2015-03-04T16:13:59","date_gmt":"2015-03-04T21:13:59","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=news&#038;p=47205"},"modified":"2015-05-15T18:33:20","modified_gmt":"2015-05-15T22:33:20","slug":"genetic-screening-test-could-identify-people-more-likely-to-benefit-from-statins","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2015\/03\/04\/genetic-screening-test-could-identify-people-more-likely-to-benefit-from-statins\/","title":{"rendered":"Genetic Screening Test Could Identify People More Likely To Benefit From Statins"},"content":{"rendered":"<p>A genetic risk score can identify people at high risk for coronary disease,\u00a0according to a <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2814%2961730-X\/abstract\">new report in the\u00a0<em>Lancet<\/em><\/a>. The score can also help find those who are most likely to benefit from statin therapy.<\/p>\n<p>The genetic risk score, derived from 27 single-nucleotide polymorphisms (SNPs), successfully identified individuals at highest risk for a cardiac event within a study population of some 50,000\u00a0people who participated in a large community-based cohort study or one of four randomized controlled statin trials. People in the highest quintile of genetic risk had a 70% greater risk for coronary heart disease than those in the bottom quintile. Similarly, statin therapy resulted in the highest relative and absolute risk reductions in those at highest risk.<\/p>\n<p>&#8220;There is ongoing debate over which individuals should be allocated statin therapy to prevent a first heart attack,&#8221; said the co-first author of the study, Nathan O. Stitziel, in a press release. &#8220;Some have said we should be treating more people, while others say we need to treat fewer. As an example of precision medicine, another approach is to identify people at high risk and preferentially prescribe statin therapy to those individuals. Genetics appears to be one way to identify high-risk patients.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A genetic risk score can identify people at high risk for coronary disease,\u00a0according to a new report in the\u00a0Lancet. The score can also help find those who are most likely to benefit from statin therapy. The genetic risk score, derived from 27 single-nucleotide polymorphisms (SNPs), successfully identified individuals at highest risk for a cardiac event [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-47205","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/47205","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=47205"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/47205\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=47205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=47205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=47205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}