{"id":47602,"date":"2015-03-23T17:34:04","date_gmt":"2015-03-23T21:34:04","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?post_type=voices&p=47602"},"modified":"2015-05-15T18:11:45","modified_gmt":"2015-05-15T22:11:45","slug":"selections-from-richard-lehmans-literature-review-march-23rd","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2015\/03\/23\/selections-from-richard-lehmans-literature-review-march-23rd\/","title":{"rendered":"Selections from Richard Lehman\u2019s Literature Review: March 23rd"},"content":{"rendered":"

CardioExchange is pleased to reprint this selection from Dr. Richard Lehman\u2019s\u00a0weekly journal review blog<\/a>\u00a0at\u00a0BMJ.com<\/a>. Selected summaries are relevant to our audience, but we encourage members to engage with the\u00a0entire blog<\/a>.<\/em><\/p>\n

JAMA 17 Mar 2015 Vol 313<\/strong><\/p>\n

Antiplatelet Therapy Duration Following Bare Metal or Drug-Eluting Coronary Stents (pg. 1113):<\/strong> This paper is based on the DAPT trial<\/a> which randomised people to receive long-term or standard duration dual antiplatelet treatment after coronary stenting. The title of the paper implies that we\u2019ll get a full report of the trial but in fact we only get the subset of 1687 patients who received bare metal stents (BMS) rather than drug-eluting stents. Continuing a combination of aspirin and a thienopyridine (clopidogrel or pasugrel) for 30 months in these patients achieved \u201cno statistically significant differences in rates of stent thrombosis, major adverse cardiac and cerebrovascular events, or moderate or severe bleeding. However, the BMS subset may have been underpowered to identify such differences, and further trials are suggested.\u201d Hmm.<\/p>\n

The BMJ 21 Mar 2015 Vol 385<\/strong><\/p>\n

School Based Education Program to Reduce Salt Intake in Children and Their Families:<\/strong> \u201cThere is compelling evidence in adults that a modest reduction in salt intake lowers blood pressure and reduces the risk of cardiovascular disease. Indeed, salt reduction is one of the most cost effective measures to prevent cardiovascular disease in both developed and developing countries.\u201d The first author on this study<\/a> is also the first author of a Cochrane review which recommends salt reduction, as opposed to other Cochrane reviews which find insufficient evidence. If looking at his references convinces you this is true, read the rest of the paper. It is all about an intervention that reduces salt intake in Chinese children. Even I think this may be a good thing, because the one thing I have against Chinese food is that it\u2019s often too salty to enjoy properly. And that is the only valid end-point when it comes to diet.<\/p>\n

\u201cThrombolysis in acute ischaemic stroke: time for a rethink?<\/a>\u201d<\/strong> is a pretty challenging title, but it turns out that Brian Alper and colleagues are only questioning its use after the three-hour mark. If you like this kind of thing, this is a very well-ordered and referenced piece of argument.<\/p>\n","protected":false},"excerpt":{"rendered":"

This week’s topics include antiplatelet therapy duration following bare metal or drug-eluting coronary stents, thrombolysis in acute ischemic stroke, and more.<\/p>\n","protected":false},"author":475,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2527,463,2526,283,1469,828,1054],"class_list":["post-47602","post","type-post","status-publish","format-standard","hentry","category-general","tag-acute-ischemi","tag-antiplatelet-therapy","tag-bare-met","tag-children","tag-drug-elut","tag-salt","tag-thrombolysis"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/47602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=47602"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/47602\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=47602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=47602"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=47602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}