{"id":5856,"date":"2011-01-06T11:56:50","date_gmt":"2011-01-06T16:56:50","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=5856"},"modified":"2011-07-19T17:44:39","modified_gmt":"2011-07-19T21:44:39","slug":"bevacizumab-in-breast-cancer-linked-to-increase-in-heart-failure-risk","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/01\/06\/bevacizumab-in-breast-cancer-linked-to-increase-in-heart-failure-risk\/","title":{"rendered":"Bevacizumab in Breast Cancer Linked to Increase in Heart Failure Risk"},"content":{"rendered":"<p><a href=\"http:\/\/jco.ascopubs.org\/content\/early\/2011\/01\/04\/JCO.2010.31.9129.abstract\">A meta-analysis in the <\/a><em><a href=\"http:\/\/jco.ascopubs.org\/content\/early\/2011\/01\/04\/JCO.2010.31.9129.abstract\">Journal of Clinical Oncology<\/a> <\/em>suggests that bevacizumab (Avastin) significantly raises the risk for heart failure when given to patients with breast cancer. Toni Choueiri and colleagues analyzed data from 3,784 patients and found a significant increase in the incidence of heart failure among those taking bevacizumab compared with those taking placebo (1.6% versus 0.4%).<\/p>\n<p>In <a href=\"http:\/\/jco.ascopubs.org\/content\/early\/2011\/01\/04\/JCO.2010.32.9060.full.pdf+html\">an accompanying editorial<\/a>, Nitin Verma and Sandra Swain write that &#8220;the results of this meta-analysis should be interpreted with extreme caution.&#8221; They point out the limitations of a meta-analysis with retrospectively collected HF data \u00a0and strongly urge that &#8220;randomized prospective trials to determine the magnitude of the potential risk, time of onset, and reversibility of heart failure with bevacizumab&#8221; be performed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A meta-analysis in the Journal of Clinical Oncology suggests that bevacizumab (Avastin) significantly raises the risk for heart failure when given to patients with breast cancer. Toni Choueiri and colleagues analyzed data from 3,784 patients and found a significant increase in the incidence of heart failure among those taking bevacizumab compared with those taking placebo [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[644,645],"class_list":["post-5856","post","type-post","status-publish","format-standard","hentry","category-heart-failure","tag-bevacizumab","tag-breast-cancer"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/5856","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=5856"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/5856\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=5856"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=5856"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=5856"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}