{"id":6365,"date":"2011-02-08T16:07:09","date_gmt":"2011-02-08T21:07:09","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=6365"},"modified":"2011-07-19T17:44:36","modified_gmt":"2011-07-19T21:44:36","slug":"biomarker-levels-post-cabg-strongly-linked-to-mortality","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/02\/08\/biomarker-levels-post-cabg-strongly-linked-to-mortality\/","title":{"rendered":"Biomarker Levels Post-CABG Strongly Linked to Mortality"},"content":{"rendered":"<p>Creatine kinase (CK-MB) and troponin levels obtained in the first day after CABG are a strong predictor of long-term mortality, according to <a href=\"http:\/\/jama.ama-assn.org\/content\/305\/6\/585.short\">a new report appearing in <\/a><em><a href=\"http:\/\/jama.ama-assn.org\/content\/305\/6\/585.short\">JAMA<\/a><\/em>. Michael Domanski and colleagues analyzed data from 7 studies that included 18,908 patients who underwent CABG and for whom data on biomarkers and mortality were available.\u00a0Mortality was closely correlated with peak CK-MB levels: the 30-day death rate ranged from 0.63% for those with a CK-MB ratio below 1 to\u00a07.06% for those with a CK-MB ratio over 20. In a multivariate model, CK-MB was the strongest predictor of mortality and persisted out to 1 year.<\/p>\n<p>Here is the increase in relative risk by CK-MB category (relative to those with CK MB &lt;1):<\/p>\n<ul>\n<li>CK-MB ratio 1 to &lt;5: 1.69 RR<\/li>\n<li>CK-MB ratio 5 to &lt;10: 2.98 RR<\/li>\n<li>CK-MB ratio 10 to &lt;20: 4.47 RR<\/li>\n<li>CK-MB ratio 20 to &lt;40: 8.73 RR<\/li>\n<li>CK-MB ratio\u00a0&gt;40: 27.01 RR<\/li>\n<\/ul>\n<p>\u201cAlthough enzyme elevations are common following CABG surgery, our data make clear that the long-term prognosis is worse for patients who experience even a small elevation of CK-MB than those who do not experience such a increase,\u201d the authors wrote.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Creatine kinase (CK-MB) and troponin levels obtained in the first day after CABG are a strong predictor of long-term mortality, according to a new report appearing in JAMA. Michael Domanski and colleagues analyzed data from 7 studies that included 18,908 patients who underwent CABG and for whom data on biomarkers and mortality were available.\u00a0Mortality was [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[686,231,687,688],"class_list":["post-6365","post","type-post","status-publish","format-standard","hentry","category-cardiac-surgery","tag-biomarkers","tag-cabg","tag-ck-mb","tag-troponins"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/6365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=6365"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/6365\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=6365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=6365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=6365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}