{"id":6448,"date":"2011-02-14T17:05:06","date_gmt":"2011-02-14T22:05:06","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=6448"},"modified":"2011-07-19T17:44:34","modified_gmt":"2011-07-19T21:44:34","slug":"crt-found-beneficial-in-less-severe-heart-failure-patients","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/02\/14\/crt-found-beneficial-in-less-severe-heart-failure-patients\/","title":{"rendered":"CRT Found Beneficial in Less Severe Heart-Failure Patients"},"content":{"rendered":"<div>\n<p>Cardiac resynchronization therapy (CRT) appears to be beneficial in patients with less severe heart failure (NYHA class I and II), according to a new systematic review <a href=\"http:\/\/www.annals.org\/content\/early\/2011\/02\/11\/0003-4819-154-6-201103150-00313.abstract?sid=28f51f8c-f640-4738-aef1-8b090cb3935e\">published online in\u00a0<em>Annals of Internal Medicine<\/em><\/a>. In a previous analysis, Nawaf Al-Majed and colleagues\u00a0had found that CRT was highly beneficial in HF patients with NYHA class III and IV symptoms. The new analysis incorporates the results of recent trials, including less symptomatic HF patients.<\/p>\n<p>The investigators analyzed data from 25 trials including 9082 patients and found a significant reduction in all-cause mortality and rehospitalizations for HF in NYHA class I and II patients. However, functional outcomes or quality of life did not improve in this group. The relative magnitude of the benefit was similar to that observed in patients with more severe HF.<\/p>\n<p>The authors conclude that their data &#8220;supports the expansion of indications for CRT to incorporate less symptomatic patients with HF who have LVEF &lt;30%, QRS duration &gt;120 msec, and are in sinus rhythm.&#8221; They estimate that CRT &#8220;may well be indicated now for most of the 40% of individuals with systolic HF who have QRS exceeding 120 msec&#8221; but acknowledge that eligibility criteria derived from randomized controlled trials is &#8220;clearly imperfect.&#8221;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cardiac resynchronization therapy (CRT) appears to be beneficial in patients with less severe heart failure (NYHA class I and II), according to a new systematic review published online in\u00a0Annals of Internal Medicine. In a previous analysis, Nawaf Al-Majed and colleagues\u00a0had found that CRT was highly beneficial in HF patients with NYHA class III and IV [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[696,542],"class_list":["post-6448","post","type-post","status-publish","format-standard","hentry","category-heart-failure","tag-cardiac-resynchronization-therapy","tag-crt"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/6448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=6448"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/6448\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=6448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=6448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=6448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}