{"id":7758,"date":"2011-04-11T14:12:28","date_gmt":"2011-04-11T18:12:28","guid":{"rendered":"http:\/\/blogs.nejm.org\/cardioexchange\/?p=7758"},"modified":"2011-07-19T17:44:28","modified_gmt":"2011-07-19T21:44:28","slug":"phentermine-topiramate-combination-yields-significant-weight-loss","status":"publish","type":"post","link":"https:\/\/blogs.nejm.org\/cardioexchange\/2011\/04\/11\/phentermine-topiramate-combination-yields-significant-weight-loss\/","title":{"rendered":"Phentermine-Topiramate Combination Yields Significant Weight Loss"},"content":{"rendered":"<p>The experimental diet drug combination of phentermine and topiramate  demonstrated \u201crobust efficacy\u201d in\u00a0 CONQUER, <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2811%2960205-5\/fulltext\">a  large new trial published online in the <em>Lancet<\/em><\/a><em>. <\/em>The trial&#8217;s results come after a year in which the FDA turned down three investigational diet drugs (including Qnexa, the phentermine-topiramate combination used here) and removed the diet drug sibutramine  from the market, leaving only one diet drug, orlistat, on the  market.<em> <\/em><\/p>\n<p>Kishore Gadde and colleagues randomized 2,487 overweight or obese  patients who had at least two comorbidities to placebo or a high- or  low-dose combination of phentermine and topiramate for 56 weeks.<\/p>\n<p>At 56 weeks, weight loss was<\/p>\n<ul>\n<li>1\u00b74 kg in the placebo group;<\/li>\n<li> 8\u00b71 kg in the low-dose combination group (p&lt;0.0001);<\/li>\n<li> 10\u00b72 kg in the high-dose combination group (p&lt;0.0001).<\/li>\n<\/ul>\n<p>At least 5% weight loss was reached by:<\/p>\n<ul>\n<li>21% of patients in the placebo group;<\/li>\n<li>62% of patients in the low-dose group (p&lt;0\u00b70001);<\/li>\n<li>70% of patients in the high-dose group (p&lt;0\u00b70001).<\/li>\n<\/ul>\n<p>The investigators also report improvements in blood pressure,  lipids, glucose control, and inflammatory markers.<\/p>\n<p>The most common side effects associated with the experimental  combination were dry mouth and paraesthesia. The investigators conclude that the side  effects either were tolerable (e.g., taste   disturbance) or could be managed by discontinuing the drug  (nephrolithiasis,  metabolic acidosis, and cognitive and psychiatric  adverse events).<\/p>\n<p>The authors write that the drug combination \u201ccould be a valuable  addition to the small arsenal of effective obesity treatments that are  available to family doctors.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The experimental diet drug combination of phentermine and topiramate demonstrated \u201crobust efficacy\u201d in\u00a0 CONQUER, a large new trial published online in the Lancet. The trial&#8217;s results come after a year in which the FDA turned down three investigational diet drugs (including Qnexa, the phentermine-topiramate combination used here) and removed the diet drug sibutramine from the [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,7],"tags":[284,796,797,355],"class_list":["post-7758","post","type-post","status-publish","format-standard","hentry","category-general","category-prevention","tag-obesity","tag-phentermine","tag-topiramate","tag-weight-loss"],"_links":{"self":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/7758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/comments?post=7758"}],"version-history":[{"count":0,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/posts\/7758\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/media?parent=7758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/categories?post=7758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.nejm.org\/cardioexchange\/wp-json\/wp\/v2\/tags?post=7758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}